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Related Experiment Video

Updated: Jul 12, 2026

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology
09:45

Microfluidics-based High-throughput Circulating Tumor Cell Sorting and Single-cell Sequencing Technology

Published on: November 14, 2025

Phenotypic Characterization and Sorting of Circulating Tumor Cells (CTCs) Using a Digital Image-Based Sorter.

Tania Rossi1, Paola Ulivi2, Michele Zanoni2

  • 1Biosciences Laboratory, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori", 47014, Meldola, Italy. tania.rossi@irst.emr.it.

Methods in Molecular Biology (Clifton, N.J.)
|July 9, 2026
PubMed
Summary

Circulating tumor cells (CTCs) are rare cancer cells in blood. Dielectrophoretic (DEP) technology aids in visualizing and isolating these rare cells for metastasis research.

Keywords:
CTCLiquid biopsyMethodsPhenotypic analysisSingle cell analysis

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Area of Science:

  • Oncology
  • Biotechnology
  • Cell Biology

Background:

  • Circulating tumor cells (CTCs) are crucial for understanding cancer metastasis.
  • Analyzing CTCs is challenging due to their extreme rarity in blood samples.

Purpose of the Study:

  • To review methods for CTC enrichment, visualization, and analysis using dielectrophoretic (DEP) technology.
  • To highlight the utility of DEP-based digital imaging and sorting for rare cell investigation.

Main Methods:

  • Dielectrophoresis (DEP)-based digital imaging and sorting for cell visualization and isolation.
  • Review of CTC enrichment techniques.
  • Phenotypic profiling and downstream analysis of isolated CTCs.

Main Results:

  • DEP technology enables visualization and isolation of single, labeled cells in heterogeneous samples.
  • DEP is valuable for investigating rare cells like CTCs.

Conclusions:

  • DEP-based methods offer a powerful approach for CTC analysis.
  • This technology facilitates a deeper understanding of metastasis mechanisms through rare cell investigation.