Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

hcHCR: High-Throughput Single-Cell Imaging of RNA in Human Primary Immune Cells.

Methods in molecular biology (Clifton, N.J.)·2024
Same author

High-throughput imaging of mRNA at the single-cell level in human primary immune cells.

RNA (New York, N.Y.)·2022
Same author

Tuberculosis Infection in Chinese Patients with Giant Cell Arteritis.

Scientific reports·2019
Same author

Protective Effects of ACY-1215 Against Chemotherapy-Related Cognitive Impairment and Brain Damage in Mice.

Neurochemical research·2019
Same author

Efficacy of laser therapy for exercise-induced fatigue: A meta-analysis.

Medicine·2019
Same author

C/EBPδ-Slug-Lox1 axis promotes metastasis of lung adenocarcinoma via oxLDL uptake.

Oncogene·2019

Related Experiment Video

Updated: Jul 12, 2026

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
09:44

Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

Published on: March 8, 2024

Multimodal Human Scalp Atlas Defines Cell Landscape and Lineage Architecture In Situ.

Edward B Li, Christopher M Stephens, Meredith Klay

    Biorxiv : the Preprint Server for Biology
    |July 10, 2026
    PubMed
    Summary
    This summary is machine-generated.

    Scientists created a detailed map of human scalp hair, revealing its growth secrets and how diseases disrupt it. This research offers new insights into hair follicle structure and potential treatments for hair loss.

    More Related Videos

    Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
    10:55

    Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

    Published on: December 16, 2017

    Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
    08:49

    Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

    Published on: August 1, 2022

    Related Experiment Videos

    Last Updated: Jul 12, 2026

    Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array
    09:44

    Recording and Analyzing Multimodal Large-Scale Neuronal Ensemble Dynamics on CMOS-Integrated High-Density Microelectrode Array

    Published on: March 8, 2024

    Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations
    10:55

    Live Imaging Followed by Single Cell Tracking to Monitor Cell Biology and the Lineage Progression of Multiple Neural Populations

    Published on: December 16, 2017

    Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy
    08:49

    Whole-Brain Single-Cell Imaging and Analysis of Intact Neonatal Mouse Brains Using MRI, Tissue Clearing, and Light-Sheet Microscopy

    Published on: August 1, 2022

    Area of Science:

    • Human biology
    • Tissue engineering
    • Genomics

    Background:

    • Human scalp hair growth is continuous but poorly understood at the cellular level.
    • Disruption of cell states and lineage organization causes inflammatory hair loss disorders.

    Purpose of the Study:

    • To create a high-resolution, multimodal atlas of the human scalp.
    • To understand cell states, lineage organization, and their disruption in hair loss.

    Main Methods:

    • Integrated deep-coverage spatial transcriptomics, single-cell RNA sequencing (scRNA-seq), and multiomics data.
    • Used live imaging to validate matrix cell organization and behavior.
    • Projected patient scRNA-seq data from alopecia areata and lichen planopilaris onto the atlas.

    Main Results:

    • Resolved spatially organized epithelial and mesenchymal states and linked transcriptional programs to chromatin accessibility.
    • Revealed human-specific hair follicle architecture and lineage progression.
    • Identified distinct cellular programs in non-scarring vs. scarring hair loss, highlighting potential diagnostic and therapeutic targets.

    Conclusions:

    • Established a foundational multimodal atlas for human hair biology.
    • Provided a framework for spatially resolved interrogation of tissue organization and disease.
    • Uncovered compartment- and state-specific pathways for hair loss disorders.