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Related Experiment Video

Updated: Jul 12, 2026

Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels
08:19

Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels

Published on: October 20, 2023

Evaluating Approaches for Inference Testing of Whole-Brain Densely Sampled Single-Subject Task fMRI Data.

Michelle C Medina, Neha A Reddy, Molly G Bright

    Biorxiv : the Preprint Server for Biology
    |July 10, 2026
    PubMed
    Summary

    Task-based functional MRI (fMRI) mapping reveals whole-brain voxel-level analysis with false discovery rate (FDR) correction offers the most sensitive and stable approach for individual functional localization, even with shorter scan times.

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    Area of Science:

    • Neuroimaging
    • Systems Neuroscience
    • Functional Magnetic Resonance Imaging (fMRI)

    Background:

    • Task-based fMRI enables precise mapping of individual brain activity patterns.
    • Current methods often focus on cortical activation, limiting systems-level understanding.
    • Statistical analysis approaches for densely sampled, whole-brain fMRI data require further development.

    Purpose of the Study:

    • To evaluate statistical analysis methods for whole-brain, task-based fMRI data.
    • To compare the sensitivity and stability of different inference approaches for individual functional localization.
    • To investigate the auditory system, including subcortical components, using multi-echo, densely sampled data.

    Main Methods:

    • Collected whole-brain, multi-echo, densely sampled fMRI data for the auditory system.

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    Last Updated: Jul 12, 2026

    Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels
    08:19

    Simultaneous Data Collection of fMRI and fNIRS Measurements Using a Whole-Head Optode Array and Short-Distance Channels

    Published on: October 20, 2023

    Brain Imaging Investigation of the Neural Correlates of Observing Virtual Social Interactions
    10:45

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    Published on: July 6, 2011

    Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
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    Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

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  • Evaluated whole-brain approaches: voxel-level and cluster-level inference with varying thresholds, non-parametric permutation inference.
  • Assessed region-specific approaches: top % t-statistics and non-parametric permutation inference.

    • Main Results:

    • Whole-brain voxel-level analysis with false discovery rate (FDR) correction (p<0.05) demonstrated the highest sensitivity and consistency in detecting auditory regions across subjects and scan durations.
    • Region-specific top % t-statistic analysis showed utility as an exploratory tool.
    • Both whole-brain and region-specific approaches provided valuable insights into functional localization.

    Conclusions:

    • Whole-brain voxel-level analysis with FDR correction is a robust method for individual functional localization in task-based fMRI.
    • Region-specific top % t-statistic analysis can complement standard methods for exploratory functional mapping.
    • Further research into statistical analysis is crucial for advancing systems-level fMRI studies.