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Measurement of Fluid Pressure01:16

Measurement of Fluid Pressure

Fluid pressure is commonly measured using devices called manometers, which rely on liquid columns to indicate pressure differences. The height of a liquid column in a manometer reflects the pressure exerted by the fluid, providing a simple yet effective means of measurement. Different types of manometers serve specific purposes based on their configurations and the type of fluids involved.
A basic form of manometer is the piezometer, a vertical tube open at the top and filled with the same...

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Related Experiment Video

Updated: Jul 12, 2026

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows
07:53

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows

Published on: April 25, 2013

Measuring Perfusion Pressure and Flow Resistance in a Microfluidic Device Using an External Optical System.

Matthew C Coughlin1,2, Marie A Floryan3,4, Giovanni S Offeddu3,4

  • 1Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115.

Journal of Micro and Nano Science and Engineering
|July 10, 2026
PubMed
Summary

Researchers developed a novel optical system to measure fluid flow and pressure in microphysiological systems (MPS). This advancement allows for accurate quantification of physical forces, crucial for replicating human disease pathology in vitro.

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Last Updated: Jul 12, 2026

Micro-particle Image Velocimetry for Velocity Profile Measurements of Micro Blood Flows
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Area of Science:

  • Biomedical Engineering
  • Microfluidics
  • Physiological Systems Modeling

Background:

  • Vascularized microphysiological systems (MPS) are increasingly used to study human disease pathology.
  • Accurate replication of physiological function in MPS requires appropriate physical forces on cellular components.
  • Quantification of physical forces, particularly fluid dynamics, within MPS has been a significant challenge.

Purpose of the Study:

  • To develop a simple, robust, and optically-based system for quantitative characterization of fluid flow in MPS.
  • To measure both driving fluid pressure and flow resistance within microphysiological platforms.
  • To ensure the system is compatible with long-term biological studies requiring maintained sterility.

Main Methods:

  • An optically-based system was designed to interface with existing pumps for quantitative flow assessment.
  • The system measured fluid pressure and flow resistance through microphysiological platforms, including glass capillary tubes and model vascular networks.
  • Benchmarking involved comparison with hydrostatic methods and theoretical predictions for laminar flow.

Main Results:

  • The developed system demonstrated excellent qualitative and quantitative agreement with established resistance measurement techniques.
  • Measurements of driving pressure and vascular resistance in an MPS within an incubator were consistent with published data.
  • The non-contact optical nature of the system preserves sterility, making it suitable for prolonged biological experiments.

Conclusions:

  • A novel, non-invasive optical system effectively quantifies fluid pressure and resistance in microphysiological systems.
  • This technology enhances the physiological relevance of MPS by enabling precise control and measurement of physical forces.
  • The system provides a valuable tool for advancing in vitro models of human disease pathology and vascular research.