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Related Concept Videos

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Related Experiment Video

Updated: Jul 12, 2026

Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Suspended Microbubbles With Ultrasound Visualization and Sustained Drug Release Properties for Enhancing

Junyi Xie1, Tianmin Tang1, Meijuan Ling1

  • 1School of Biomedical Engineering, Shenzhen Campus of Sun Yat-Sen University, Shenzhen, China.

Small (Weinheim an Der Bergstrasse, Germany)
|July 10, 2026
PubMed
Summary
This summary is machine-generated.

Researchers developed novel suspended microbubbles loaded with 5-fluorouracil (5-Fu-MBs) for peritoneal carcinomatosis. This drug delivery system enhances treatment efficacy and reduces toxicity compared to traditional methods.

Keywords:
5‐fluorouracilintraperitoneal perfusionsuspended microbubblessustained drug releaseultrasound‐enhanced contrast

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Area of Science:

  • Oncology
  • Biomedical Engineering
  • Drug Delivery Systems

Background:

  • Peritoneal carcinomatosis (PC) is a widespread cancer metastasis treated with intraperitoneal perfusion.
  • Current treatments face limitations due to rapid drug metabolism and short efficacy.
  • Existing local scaffold treatments show limited effectiveness in eradicating tumors.

Purpose of the Study:

  • To develop an advanced drug delivery system for improved PC treatment.
  • To create suspended microbubbles (MBs) for enhanced drug distribution and sustained release.
  • To evaluate the therapeutic efficacy and safety of 5-fluorouracil-loaded MBs (5-Fu-MBs).

Main Methods:

  • Development of suspended MBs with saline-similar density for uniform peritoneal distribution.
  • Loading MBs with 5-fluorouracil (5-Fu) to create 5-Fu-MBs.
  • Utilizing ultrasound for enhanced contrast and real-time monitoring of MB distribution.
  • Conducting animal experiments comparing 5-Fu-MB perfusion with conventional 5-Fu solution.

Main Results:

  • 5-Fu-MBs demonstrated stable suspension and uniform distribution within the peritoneal cavity.
  • Ultrasound imaging allowed real-time monitoring of 5-Fu-MB distribution.
  • 5-Fu-MB perfusion showed significantly superior therapeutic efficacy compared to conventional 5-Fu solution.
  • The 5-Fu-MB treatment exhibited lower biotoxicity.

Conclusions:

  • Suspended 5-Fu-MBs offer enhanced suspension stability and ultrasound contrast properties.
  • This novel system provides sustained drug release, extending therapeutic duration.
  • 5-Fu-MBs show promise for treating PC and potential applications in localized precision therapy.