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Sample Preparation to Bioinformatics Analysis of DNA Methylation: Association Strategy for Obesity and Related Trait Studies
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Multi-omics Analysis Identify Novel Microbiome-Metabolome Signatures Associated with Obesity.

Bo Tian1, Yong Liu1, Kuan-Jui Su2

  • 1Center for System Biology, Data Sciences, and Reproductive Health, School of Basic Medical Science, Central South University, 172 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.

Journal of Applied Microbiology
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PubMed
Summary

This study reveals how gut bacteria and serum metabolites interact to influence obesity. Key bacteria like Bacteroides fragilis and metabolites such as glycine show significant associations with body mass index.

Keywords:
BMIMetagenomicsmetabolomemulti-omicsobesity

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Area of Science:

  • Microbiome research
  • Metabolomics
  • Obesity research

Background:

  • Obesity is a complex metabolic disorder with multifactorial causes.
  • The gut microbiome and serum metabolome play crucial roles in host metabolism.
  • Understanding the interplay between these factors is vital for developing effective obesity interventions.

Purpose of the Study:

  • To explore the potential microbiome and serum metabolome factors associated with obesity.
  • To investigate the interactions between gut bacteria and serum metabolites in the context of obesity.
  • To provide systemic insight into microbiome-host metabolic interactions related to obesity.

Main Methods:

  • Systematic multi-omics analysis of paired metagenomic and metabolomic profiles.
  • Included untargeted serum metabolomics, lipidomics, and short-chain fatty acids (SCFAs) analysis.
  • Utilized a cohort of 495 US men, with validation in an independent Chinese cohort.

Main Results:

  • Identified 52 gut bacteria species and 31 serum metabolites associated with body mass index (BMI).
  • Key bacteria associations: Collinsella stercoris (negative), Bacteroides fragilis (positive), Veillonella dispar (positive).
  • Significant metabolite associations include gamma-glutamylglycine, asparagine, glycine, and serotonin, interacting with specific bacteria.

Conclusions:

  • This multi-omics study identifies key gut bacteria and serum metabolites that interact to associate with host obesity.
  • Provides systemic insight into microbiome-host metabolic interactions.
  • Highlights specific microbial and metabolic signatures linked to obesity.