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Updated: Jul 12, 2026

Evidence-based Knowledge Synthesis and Hypothesis Validation: Navigating Biomedical Knowledge Bases via Explainable AI and Agentic Systems
Published on: June 13, 2025
Seeing is Believing? Credibility and Behavioral Intentions Toward Evidence-Based and Misleading Health Information
Tong Lin1, Dylan D Wagner2, Daphine Choy2
1College of Public Health, The Ohio State University, Columbus, OH, USA.
None:
PurposeTo examine how adults respond to real-world health videos that vary in credibility.DesignRandomized, within-subjects online experiment.SettingOnline U.S. survey.Sample179 adults recruited from an online panel.InterventionParticipants viewed one misleading and one evidence-based health video, in randomized order.MeasuresBefore viewing, participants reported trust in traditional and social media. After each video, they rated perceived information credibility (PIC) and perceived source credibility (PSC), relevance, and behavioral intention to adopt the recommended behavior. Demographic data were also collected.AnalysisPaired-samples t-tests and hierarchical linear regressions examined responses to evidence-based vs misleading videos and associations among the variables.ResultsThe evidence-based video was rated higher for relevance (t (178) = -4.93, P < .001), PSC (t (178) = -11.36, P < .001), PIC (t (178) = -10.61, P < .001), and intention (t (178) = 5.73, P < .001). For both videos, PSC and relevance were positively associated with intention. Trust in traditional media was related to higher PSC (b = .43, P < .001) and PIC (b = .35, P < .001) of the evidence-based content, whereas trust in social media was related to higher PSC (b = .46, P < .001) and PIC (b = .33, P = .022) of the misleading content. Higher education was associated with a better ability to distinguish between the PSC and PIC of the two videos (ps < .01).ConclusionsFindings highlight psychological and contextual factors shaping engagement with online health information and the importance of speaker credibility and platform trust in promoting informed health decision-making.
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