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Related Concept Videos

Pharmacodynamics in Geriatric Patients: Effects of Age01:27

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution01:00

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution

Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Related Experiment Video

Updated: Jul 12, 2026

Therapeutic Massage for Psychological Well-being in Geriatric Oncology
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Published on: May 22, 2026

Consensus research priorities in geriatric oncology: A Delphi study.

Amanda Drury1, Aoife O'Brien2, Sarah Sheehan3

  • 1School of Nursing and Midwifery, Trinity College Dublin, 24 D'Olier Street, Dublin 2, Ireland..

Journal of Geriatric Oncology
|July 10, 2026
PubMed
Summary

Older adults living with or after cancer need research focused on treatment development, decision-making, and integrated care. This study identified key geriatric oncology survivorship priorities through expert consensus.

Keywords:
Cancer survivorshipDelphi studyGeriatric oncologyOlder adultsResearch priorities

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Area of Science:

  • Geriatric Oncology
  • Cancer Survivorship Research
  • Health Services Research

Background:

  • Meaningful involvement of older adults in cancer survivorship research is limited globally.
  • Priorities for geriatric oncology survivorship research need to be established, especially outside North America.

Purpose of the Study:

  • To establish consensus on key research priorities in geriatric oncology survivorship.
  • To incorporate the perspectives of older adults living with or after cancer and other stakeholders.

Main Methods:

  • Modified Delphi methodology involving 60 experts (including older adults, caregivers, healthcare professionals, researchers).
  • Assessment of 55 research priorities across four Delphi rounds.
  • Consensus defined as ≥80% agreement.

Main Results:

  • 37 research priorities achieved consensus.
  • Top priorities include treatment development (98%), decision-making (96%), healthcare professional awareness of cancer symptoms in older adults (96%), rehabilitation programs (96%), and management of multimorbidity (96%) and frailty (96%).

Conclusions:

  • A consensus-based framework for geriatric oncology survivorship research priorities was established.
  • Treatment development is a key priority, alongside research in decision-making, integrated care, and rehabilitation.
  • Findings emphasize the need to address the holistic needs of older adults living with and after cancer.