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Updated: Jul 12, 2026

A Simple and Efficient Protocol for the Catalytic Insertion Polymerization of Functional Norbornenes
Published on: February 27, 2017
Pd/Norbornene-Catalyzed Tandem o-C-H Alkylation or Acylation/ipso-Intramolecular Direct Arylation of Aryl Bromides
Mingruo Ding1,2, Min Liu3, Zenghui Ye4
1School of Pharmacy, Jiangxi Science & Technology Normal University, Nanchang 330013, P. R. China.
Abstract:
A novel palladium-catalyzed, norbornene-mediated ortho-intermolecular C-H functionalization/ipso-intramolecular direct arylation of aryl bromides is reported. Through careful tuning of the reaction conditions, ortho-alkylation and acylation of aryl bromides have been realized with good efficiency. This method provides a novel route to afford abundant polycyclic and heteroaromatic compounds from simple and readily available raw material under mild conditions. This transformation is scalable and tolerates a broad range of functional groups.
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