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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin create...
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
Acute Inflammation III: Local and Systemic Effects01:25

Acute Inflammation III: Local and Systemic Effects

Acute inflammation produces a coordinated set of local and systemic changes that limit injury, eliminate pathogens, and initiate repair. These responses arise within minutes of infection, trauma, or chemical insult and are driven by vascular alterations and leukocyte-derived mediators. When the stimulus resolves, the reaction typically abates within days.Local EffectsAt the site of injury, arteriolar vasodilation increases blood flow, resulting in redness and warmth. Simultaneously, increased...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies. Common...

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Related Experiment Video

Updated: Jul 12, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

Risk factors for sepsis: a systematic review and meta-analysis.

Chu Qin1,2, Sisi Lin1, Lisha Pang3

  • 1School of Public Health, Zhejiang Chinese Medical University, Hangzhou, China.

Frontiers in Public Health
|July 11, 2026
PubMed
Summary

This systematic review identified 18 key risk factors and 1 protective factor for sepsis incidence. Early identification and intervention are crucial for sepsis prevention and reducing its occurrence.

Keywords:
incidencemeta-analysisrisk factorssepsissystematic review

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A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Related Experiment Videos

Last Updated: Jul 12, 2026

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

Area of Science:

  • Medical research
  • Public health
  • Epidemiology

Background:

  • Sepsis remains a significant global health challenge with high morbidity and mortality.
  • Effective primary prevention and early identification strategies are essential for improving patient outcomes.

Purpose of the Study:

  • To systematically review and meta-analyze existing literature to identify key risk factors for sepsis incidence.
  • To provide evidence-based insights for the primary prevention and early detection of sepsis.

Main Methods:

  • A comprehensive systematic search was conducted across eight major Chinese and English databases.
  • Two independent reviewers performed study selection, data extraction, and quality assessment.
  • Meta-analysis was performed using RevMan software, with fixed- or random-effects models and sensitivity analyses.

Main Results:

  • 12,536 records were screened, and 23 studies met eligibility criteria, with 21 included in the meta-analysis.
  • Eighteen significant risk factors for sepsis incidence were identified, including advanced age, male sex, low BMI, diabetes, COPD, cancer, kidney disease, and postoperative infection.
  • Antibiotic use emerged as a significant protective factor against sepsis incidence.

Conclusions:

  • This study offers a comprehensive overview of factors associated with sepsis incidence.
  • Prioritizing the identification of these risk factors and implementing timely interventions can significantly reduce sepsis incidence.