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Updated: Jul 12, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

Left atrial dysfunction in different morphologic phenotypes of hypertrophic cardiomyopathy: a cardiac magnetic

Yiyuan Gao1,2, Wenqi Liu2, Zhan Feng3

  • 1Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Quantitative Imaging in Medicine and Surgery
|July 11, 2026
PubMed

Insights

Hypertrophic cardiomyopathy (HCM) patients show impaired left atrial (LA) function across subtypes. Concentric HCM exhibits more severe LA dysfunction than septal HCM, highlighting subtype-specific mechanics.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Biomedical Engineering

Background:

  • Hypertrophic cardiomyopathy (HCM) presents diverse phenotypes, but left atrial (LA) function differences among subtypes are not well understood.
  • Cardiac magnetic resonance feature tracking (CMR-FT) can quantify LA deformation, but its use for subtype-specific mechanics is limited.

Purpose of the Study:

  • To investigate LA functional impairment in different HCM phenotypic subtypes using CMR-FT.
  • To characterize subtype-specific alterations in atrial mechanics.

Main Methods:

  • Retrospective analysis of 225 HCM patients (septal, apical, concentric) and 68 healthy controls (HC).
  • LA functional parameters (reservoir strain εs, conduit strain εe, booster strain εa) measured using CMR-FT.
  • Statistical analysis including ANOVA and regression to compare LA function and correlate with left ventricular parameters.

Main Results:

  • All HCM subgroups displayed significantly impaired LA strain compared to HC (P<0.05).
  • Concentric HCM showed more severe LA reservoir (εs) and booster (εa) strain impairment than septal HCM (P<0.05).
  • CMR-FT demonstrated excellent reproducibility for LA strain measurements (ICCs >0.75).

Conclusions:

  • Left atrial dysfunction varies significantly across HCM phenotypes.
  • Concentric HCM exhibits greater impairment in LA reservoir and booster function compared to septal HCM.
  • CMR-FT is a valuable tool for phenotypic characterization of HCM by assessing subtype-specific atrial mechanics.
Abstract

Keywords:
Hypertrophic cardiomyopathy (HCM)cardiac magnetic resonance feature tracking (CMR-FT)left atrial function (LA function)morphologic phenotypestrain

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