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Evolution in lung IRI cell death research: a 20-year global bibliometric study (2005-2024).
Haoshuai Yang1, Bojun Xu2, Zihan Wang1
1Department of Thoracic Surgery, China-Japan Friendship Hospital, Beijing, P.R. China.
Annals of Medicine and Surgery (2012)
|July 11, 2026
Summary
Lung ischemia-reperfusion injury (LIRI) research is evolving. Studies now focus on ferroptosis and other cell death pathways beyond apoptosis, with the US and China leading global output.
Area of Science:
- Transplantation immunology
- Pathology
- Biomedical research trends
Background:
- Lung ischemia-reperfusion injury (LIRI) is critical in primary graft dysfunction after lung transplantation.
- Regulated cell death (RCD) pathways like apoptosis, ferroptosis, and pyroptosis are key LIRI drivers.
- Existing LIRI research is fragmented, lacking a cohesive knowledge structure.
Purpose of the Study:
- To conduct a comprehensive bibliometric analysis of LIRI research.
- To map publication trends, collaborations, and thematic evolution in LIRI.
- To identify emerging research frontiers and knowledge gaps in LIRI.
Main Methods:
- Bibliometric analysis of 2462 English-language articles (2005-2024) from Web of Science Core Collection.
- Utilized CiteSpace, VOSviewer, and Bibliometrix for data analysis.
- Examined publication trends, international collaborations, keyword co-occurrence, and co-citation networks.
Main Results:
- The US (941) and China (809) dominate global LIRI publications.
- Research has shifted from inflammation/apoptosis to ferroptosis, mitophagy, and exosomes.
- "Ferroptosis" emerged as a leading research frontier in 2022-2023.
- US and Chinese research ecosystems drive experimental and theoretical innovation, respectively, with limited collaboration.
Conclusions:
- LIRI research is moving towards a multidimensional framework beyond classical paradigms.
- The US-China dual-core structure and integrated basic-clinical studies show convergence.
- This bibliometric map provides a strategic reference for future translational and therapeutic LIRI research.
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