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The microbiome-gut-brain axis: a new perspective on the pathogenesis and intervention of frailty
1Department of Geriatrics, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China.
Abstract:
With the acceleration of global aging, frailty syndrome has become an important public health challenge. This article reviews the new perspective of the microbiome-gut-brain axis (MGBA) in the pathogenesis and intervention strategies of frailty, and systematically analyzes the bidirectional association between the gut microbiome and frailty, the potential biological mechanisms, and the therapeutic progress targeting the microbiome. Evidence shows that microbiome-gut-brain axis (MGBA) plays a pivotal role in frailty, and its regulation not only helps to reveal the multidimensional nature of frailty, but also provides important directions for the development of novel biomarkers and personalized interventions. Multi-dimensional targeting of MGBA may be an effective way to promote healthy aging.
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