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Related Experiment Video

Updated: Jul 13, 2026

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

Published on: October 17, 2016

Stress-Adaptive Biomaterials With Tunable Yielding Architectures Regulate Organoid Morphogenesis.

James P W Reeves1, Sabra Rostami1, Mostafa Rammal2

  • 1Department of Chemical Engineering, McGill University, Montreal, Quebec, Canada.

Small (Weinheim an Der Bergstrasse, Germany)
|July 11, 2026
PubMed
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Biomaterial yield stress controls tissue growth and organization. Researchers developed a tunable granular hydrogel platform to precisely adjust yield stress, demonstrating its impact on cancer cell migration and neural organoid development for regenerative medicine applications.

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biophysics

Background:

  • The yield stress of biomaterials, a critical factor in plastic deformation, limits stress development in growing encapsulated tissues.
  • While matrix stiffness and viscoelasticity are known to influence cells, the specific role of yield stress has been difficult to ascertain.

Purpose of the Study:

  • To engineer a granular hydrogel platform enabling precise, quantitative tuning of biomaterial yield stress.
  • To investigate the impact of tunable yield stress on cellular behaviors, including cancer cell migration and neural organoid development.

Main Methods:

  • Development of a granular hydrogel using supramolecular host-guest dynamic crosslinkers for tunable yield stress.
  • Quantitative measurement and adjustment of matrix yield stress between 12 and 370 Pa, with storage modulus below ~0.1 kPa.
Keywords:
3D culturedevelopmentgranular gelgrowth‐induced stressmechanical plasticitymechanobiologymidbrainrosetteyield stress

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Last Updated: Jul 13, 2026

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size
13:46

A Facile and Eco-friendly Route to Fabricate Poly(Lactic Acid) Scaffolds with Graded Pore Size

Published on: October 17, 2016

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink
08:34

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

Published on: April 21, 2016

  • Application of the hydrogel platform to model non-adhesive cancer migration and early-stage midbrain organoid development.

    • Main Results:

    • The tunable yield stress range was found to effectively promote or inhibit peripheral shedding in a cancer migration model.
    • Early development of midbrain organoids demonstrated exquisite sensitivity to matrix yield stress, with specific values influencing neural rosette formation.
    • Yield stresses as low as 25 Pa significantly promoted bud-like protrusions and neural rosettes, while 10 Pa variations limited these developmental phenotypes.

    Conclusions:

    • Biomaterial yield stress is a critical mechanical parameter that can be precisely controlled to influence tissue morphogenesis and organization.
    • This tunable yield stress platform offers a novel approach for designing biomaterials for advanced disease modeling and regenerative medicine applications.