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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

Site-Targeted Drug Delivery Systems: Polymeric Carriers

Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
Modified-Release Drug Delivery Systems: Overview01:19

Modified-Release Drug Delivery Systems: Overview

Modified-release dosage forms are designed to address the limitations of drugs with short biological half-lives. These forms maintain stable therapeutic drug concentrations over extended periods, reducing the need for frequent dosing. A consistent drug level helps minimize peak-trough fluctuations, which can reduce adverse effects, lower the risk of drug resistance, and improve overall treatment effectiveness.One common type of modified-release form is the extended-release (ER) formulation. ER...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...

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Updated: Jul 13, 2026

Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
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Encapsulation of Protein-Based Drug Carriers for Controlled Loading and Releasing Efficiency: A Review.

Mahadesh Chandro Mondal1, H M Wasi Uddin1, Sania Ashrafi2

  • 1Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, Dhaka, 1000, Bangladesh.

The Protein Journal
|July 11, 2026
PubMed
Summary

Protein nanoparticles offer enhanced drug delivery by improving stability and controlled release for various diseases. Further research is needed to overcome challenges and enable clinical translation of these promising therapeutic systems.

Keywords:
Controlled releaseEncapsulationLoadingNanoparticlesProtein-based drugs

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09:03

Manufacture and Drug Delivery Applications of Silk Nanoparticles

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Protein nanoparticles are increasingly recognized for their biocompatibility, biodegradability, and tunable properties, making them ideal for drug delivery.
  • These nanoparticles have shown potential in treating neurological disorders, infections, tumors, and cancer by sustaining therapeutic activity.
  • Various proteins like albumin, gelatin, and silk fibroin are utilized with methods including coacervation and self-assembly.

Purpose of the Study:

  • To review the chemical and structural properties of protein nanoparticles for drug delivery.
  • To highlight advancements in encapsulation methodologies and key parameters for loading and release efficiency.
  • To analyze drug stabilization, loading, and release profiles in relation to therapeutic performance.

Main Methods:

  • Review of existing literature on protein nanoparticle encapsulation strategies.
  • Analysis of chemical and structural properties of various protein carriers.
  • Evaluation of encapsulation techniques like coacervation, self-assembly, emulsification, and ionotropic gelation.

Main Results:

  • Protein nanoparticles demonstrate significant advantages in drug delivery, including enhanced stability, bioavailability, and controlled release.
  • Key parameters influencing loading and release efficiency have been identified.
  • Successful applications in treating diverse conditions such as cancer and neurological disorders were observed.

Conclusions:

  • Protein nanoparticle encapsulation holds great potential for improving drug design and developing safer, more effective therapeutics.
  • Challenges like enzymatic degradation and pH sensitivity need to be addressed for successful clinical translation.
  • Continued research is crucial to realize the full clinical impact of protein-based drug delivery platforms.