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Related Concept Videos

Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

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Corrigendum to "A comprehensive study on mechanisms of action of fibroin, aloe vera, and ginger extracts through histochemical, inflammation biomarkers, and matrix metalloproteinases analysis against diabetic wounds" [J Tissue Viability 33 (2024) 949-959].

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Updated: Jul 12, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

G6PD: An Old Player with Multiple Emerging Roles from Cancer Progression to Metastasis and Chemoresistance.

Lubna Kanwal1, Vishal Haer2, Habiba Anum3

  • 1Department of Zoology, University of Okara, Okara, Pakistan. lubna.kanwal@uo.edu.pk.

The Protein Journal
|July 9, 2026
PubMed
Summary

Glucose-6-phosphate dehydrogenase (G6PD) fuels cancer growth and metastasis by regulating nucleotide synthesis and redox balance. Targeting G6PD offers new therapeutic strategies for cancer treatment.

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Last Updated: Jul 12, 2026

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies
07:29

Studying Pancreatic Cancer Stem Cell Characteristics for Developing New Treatment Strategies

Published on: June 20, 2015

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Glucose-6-phosphate dehydrogenase (G6PD) is the key enzyme in the pentose phosphate pathway (PPP).
  • G6PD activity is crucial for providing NADPH for redox balance and ribose-5-phosphate for nucleotide synthesis.
  • Dysregulation of G6PD is increasingly linked to cancer progression and chemotherapy tolerance.

Purpose of the Study:

  • To elucidate the molecular mechanisms driving G6PD hyperactivation in cancer.
  • To review novel regulatory mechanisms of G6PD, including post-translational, protein-interaction, and epitranscriptomic controls.
  • To explore the predictive and therapeutic potential of G6PD in cancer treatment.

Main Methods:

  • Literature review of molecular mechanisms, regulatory controls, and therapeutic strategies related to G6PD in cancer.
  • Analysis of G6PD's role in proliferation, epithelial-mesenchymal transition (EMT), and metastatic niche adaptation.
  • Investigation of G6PD's involvement in nucleotide synthesis and antioxidant defense.

Main Results:

  • G6PD hyperactivation promotes tumor proliferation, EMT, and adaptation to metastatic environments.
  • New insights into post-translational, protein-interaction, and epitranscriptomic regulation of G6PD are presented.
  • G6PD's function in nucleotide synthesis and antioxidant defense contributes to treatment resistance.

Conclusions:

  • G6PD plays a significant and multifaceted role in cancer development and progression.
  • Targeting G6PD through novel inhibitors and combination strategies holds promise for transforming cancer therapy.
  • Further research into G6PD's predictive and therapeutic potential is warranted.