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Related Experiment Video

Updated: Jul 13, 2026

Crystallization of Membrane Proteins in Lipidic Mesophases

Crystallization of Membrane Proteins in Lipidic Mesophases

Published on: March 28, 2011

Interfacial Entropy Drives Crystallization of Covalent Framework Membranes for Precise Ionic Separation.

Kai Liu¹, Congcong Yin¹, Ziyin Zhang¹

¹Key Lab of Functional Polymers For Sustainability of Jiangsu, School of Energy and Environment, Southeast University, Nanjing, Jiangsu, P. R. China.

Angewandte Chemie (International Ed. in English)

|July 11, 2026

Summary

We developed an entropy-regulated crystallization strategy for fabricating highly crystalline covalent organic framework (COF) membranes. This method enhances membrane performance for efficient ion separation, overcoming previous limitations in material processing and structural regularity.

Keywords:

asymmetric covalent organic frameworks entropy interfacial crystallization ionic separation

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Last Updated: Jul 13, 2026

Crystallization of Membrane Proteins in Lipidic Mesophases

Crystallization of Membrane Proteins in Lipidic Mesophases

Published on: March 28, 2011

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes

Electrophoretic Crystallization of Ultrathin High-performance Metal-organic Framework Membranes

Published on: August 16, 2018

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

Crystallizing Membrane Proteins for Structure Determination using Lipidic Mesophases

Published on: November 21, 2010

Area of Science:

Materials Science
Chemical Engineering
Nanotechnology

Background:

Fabricating highly crystalline covalent organic framework (COF) membranes is crucial for efficient mass transport.
Achieving crystalline COF membranes faces challenges due to the trade-off between structural regularity and processability.

Purpose of the Study:

To develop a novel strategy for fabricating highly crystalline COF membranes.
To improve membrane performance for separation applications by controlling crystallization.

Main Methods:

An entropy-regulated interfacial crystallization strategy was employed.
Ion-dipole interactions were introduced to reduce monomer configurational entropy, promoting ordered preorganization.
Solvent-mediated diffusion was utilized to induce framework growth, creating an asymmetric membrane structure.

Main Results:

The strategy redirected membrane formation from disorder to thermodynamically favored crystallization.
The resulting asymmetric membrane features a dense, highly crystalline selective layer and a fibrous macroporous sublayer.
The membrane exhibited long-range ordered channels, a high surface area (1721 m² g⁻¹), enhanced mechanical robustness, a high Cs⁺ permeation rate (0.17 mol m⁻² h⁻¹), and exceptional Cs⁺/La³⁺ selectivity (292).

Conclusions:

Interfacial entropy regulation is a general and effective route for controlling crystallization in interfacial systems.
This work provides new insights into the rational fabrication of framework-based separation membranes.
The developed COF membranes show significant potential for advanced separation applications.