Related Experiment Video
Updated: Jul 13, 2026

Preparation of Naringenin Solution for In Vivo Application
Published on: August 10, 2021
Potential advantages of the combinatorial use of naringenin/naringin with clinically approved drugs
1Research Center for Quality and Efficacy Re Evaluation of Post-Marketed TCM, Guangdong Provincial Key Laboratory of Plant Stress Biology, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, 510275, PR China.
Abstract:
Single-target therapies face growing constraints from complex disease etiologies, dose-limiting toxicities, and drug resistance. Integrating multi-target natural products into conventional regimens offers a promising synergistic strategy. Naringenin and naringin, well-defined flavanones with broad bioactive properties, exhibit multi-target profiles that make them attractive candidates for drug combination. This review consolidates evidence on the synergistic efficacy and organ-protective effects of these flavonoids combined with clinically approved drugs. Through pleiotropic mechanisms, these combinations enhance therapeutic efficacy while mitigating adverse effects. We systematically discuss the underlying pharmacological mechanisms, synthesizing a framework that decodes the interplay between pharmacokinetic modulation and pharmacodynamic engagement. Overall, these findings highlight the potential of naringenin and naringin as versatile adjuvants, providing insights for developing improved, multi-target clinical regimens.
Related Concept Videos
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Antianginal Drugs: Nitrates and β-Blockers
Organic nitrates, such as nitroglycerin, play a pivotal role. Once metabolized, they liberate nitric oxide, a molecular marvel. Nitric oxide triggers guanylyl cyclase and augments cGMP production. This biochemical cascade orchestrates the relaxation of vascular smooth muscles, ushering in vasodilation and enhancing coronary blood flow. Administered...
Drug toxicity: Drug–Drug Interaction
Impact of Pharmacokinetic–Pharmacodynamic Models: Regulatory Decisions
Antianginal Drugs: Calcium Channel Blockers and Ranolazine
CCBs, a diverse class that includes dihydropyridines (nifedipine) and diphenylalkylamines (verapamil and diltiazem), exert their effect by blocking calcium channels in cardiac and smooth muscle cells. This...
Bioequivalence of Drugs: Drugs with Multiple Indications