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Updated: Jul 13, 2026
Autologous Microfractured and Purified Adipose Tissue for Arthroscopic Management of Osteochondral Lesions of the Talus
Published on: January 23, 2018
Comparison of arthroscopic microfracture efficacy in osteochondral lesions of the talus with and without urate
Yuanqiang Li1, Lili Hu1, Ye Yang1
1Sports Medicine Center, First Affiliated Hospital of The Army Medical University, No. 30, Gaotanyan Street, Shapingba District, Chongqing 400038, China.
Objective:
To compare arthroscopic microfracture efficacy between talar osteochondral lesion (OLT) patients with and without monosodium urate (MSU) deposition, and identify poor prognosis risk factors.
Methods:
Sixty-one OLT patients were stratified into MSU (n = 26) and non-MSU (n = 35) groups, followed ≥ 24 months. Outcomes were assessed using VAS, AOFAS and MOCART scores. Multivariate logistic regression was performed.
Results:
MSU group had higher preoperative uric acid (516.37 ± 63.36 vs 342.57 ± 60.83 μmol/L, P < 0.001), higher postoperative VAS (1.43 ± 0.77 vs 0.83 ± 0.42, P = 0.001), lower AOFAS (81.09 ± 8.26 vs 86.44 ± 9.65, P = 0.027) and inferior MOCART scores (lower complete defect filling, P = 0.042). MSU deposition (OR=1.988, P = 0.002) and large defects (OR=2.234, P = 0.001) were independent risk factors. Complication rate was higher in MSU group (30.77% vs 5.71%, P = 0.032).
Conclusion:
MSU crystal deposition significantly impairs clinical outcomes and cartilage repair after OLT microfracture, representing an independent adverse prognostic factor.
