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Updated: Jul 14, 2026
Detection of Rare Mutations in CtDNA Using Next Generation Sequencing
Published on: August 24, 2017
Current Evidence for Circulating Tumor DNA in Sarcoma: Challenges and Opportunities for Clinical Application
Kristin E Goodsell1, Jason A Carter1, Hannah R Abrams2,3
1Department of Surgery, University of Washington, Seattle, Washington, USA.
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Sarcomas represent a diverse group of mesenchymal tumors with high rates of recurrence after resection. While recent technical advances have enabled the detection of rare circulating tumor DNA (ctDNA) in other malignancies, the complexity and heterogeneity of sarcoma genomics have historically limited ctDNA in these cancers. This narrative review highlights the rapidly evolving evidence supporting potential clinical applications of ctDNA in common sarcoma subtypes including gastrointestinal stromal tumor, leiomyosarcoma, rhabdomyosarcoma, osteosarcoma, and Ewing sarcoma.
