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Potential Refractive Error Due to Axial Displacement of Intraocular Lenses with Clinically Relevant Compression
Andrew Maxwell1, James S Marotta2, Maddi McGough2
1InSight Vision Center, California Eye Institute, Fresno, CA, USA.
Clinical Ophthalmology (Auckland, N.Z.)
|July 13, 2026
Summary
Clareon intraocular lenses (IOLs) demonstrated superior mechanical stability and lower potential refractive error (RE) compared to other models. These findings suggest Clareon IOLs may reduce the risk of refractive errors, particularly in certain eye types.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Materials Science
Background:
- Intraocular lens (IOL) mechanical stability is crucial for predictable refractive outcomes.
- Capsular bag diameter (CBD) varies among patients, influencing IOL performance.
- Understanding IOL behavior under physiological compression is essential for clinical success.
Purpose of the Study:
- To compare the mechanical stability of 9 different intraocular lens (IOL) models.
- To assess the potential refractive error (RE) associated with IOL mechanical performance.
- To evaluate IOLs using compression diameters relevant to clinical capsular bag diameters (CBD).
Main Methods:
- In vitro bench testing of single-piece acrylic IOLs under simulated physiological conditions.
- Measurement of axial displacement, optic decentration, optic tilt, and haptic compression force.
- Calculation of potential refractive error based on axial displacement using a schematic eye model.
Main Results:
- Clareon IOL models exhibited significantly lower axial displacement and haptic compression force compared to 6 other models at 9-mm compression.
- Mechanical stability performance was not affected by optical design variations within the Clareon models.
- Optic decentration and tilt showed no statistical differences among the tested IOL models.
Conclusions:
- Clareon IOL models demonstrated superior mechanical stability, resulting in lower potential refractive error (RE).
- IOL models with significant axial displacement under compression may lead to refractive errors, especially in shorter eyes.
- The study highlights the importance of mechanical stability in IOL design for predictable visual outcomes.
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