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Updated: Jul 14, 2026
Manganese Oxide Nanoparticle Synthesis by Thermal Decomposition of Manganese(II) Acetylacetonate
Published on: June 18, 2020
Magnetic-Optical Dual-Modality Imaging Monitoring Oxaliplatin through the Crystalline Mn-Metal-Organic Framework
Yanqiu Chen1, Xingai Ge2, Fang Fang2
1Radiology department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou121001, P. R. China.
Abstract:
To support image-assisted evaluation of anticancer drugs in biological settings, functional sensing materials are needed to integrate sensitive molecular detection with imaging-compatible readouts. Oxaliplatin (OHP) is widely used in chemotherapy, and accurate OHP assessment in biological matrices remains important for dosage optimization and toxicity management. Herein, a nanosized Mn-MOF was prepared as a fluorescence sensor and MRI-responsive platform for OHP-associated detection. The structure, morphology, elemental distribution, and Mn surface electronic state of the Mn-MOF were characterized by XRD, SEM, AFM, EDS mapping, XPS, and DLS. Mn-MOF showed limited dialyzable Mn leakage, and retained fluorescence stability and MRI signal stability during 28 days of storage. As a T1 MRI contrast platform, Mn-MOF exhibited a longitudinal relaxivity (r1) of 6.38 mM-1 s-1 at 3.0 T and showed OHP-dependent T1 signal attenuation over the tested OHP concentration range of 0.5-10 mM. Preliminary in vivo MRI experiments showed liver and kidney T1 enhancement after intravenous Mn-MOF administration and OHP-associated attenuation of the Mn-MOF-enhanced signal. In fluorescence mode, the Mn-MOF nanosensor exhibited concentration-dependent quenching toward OHP in ultrapure water over 0.33 fM-18.2 μM, with a calibration-model-based estimated limit of detection (LOD) of 41.1 aM under the stated Mn-MOF-assisted fluorescence sensing conditions. The sensor also showed selectivity under the tested interference conditions, spiked-rabbit-serum calibration and recovery performance, and 28-day fluorescence response stability. Hemolysis, H&E staining, KGN and HK-2 cell-viability assays indicated preliminary hemocompatibility and cytocompatibility under the tested conditions. This dual-modal design provides a preliminary strategy for integrating optical OHP sensing with MRI readout in a single Mn-MOF platform.
Insights
A novel manganese metal-organic framework (Mn-MOF) functions as a dual-mode sensor for detecting oxaliplatin (OHP), a chemotherapy drug. This material enables sensitive fluorescence detection and MRI imaging, aiding in drug monitoring and management.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Accurate assessment of oxaliplatin (OHP) is crucial for optimizing chemotherapy dosage and managing toxicity.
- Developing integrated sensing and imaging platforms is essential for real-time evaluation of anticancer drugs in biological systems.
Purpose of the Study:
- To develop a nanosized manganese metal-organic framework (Mn-MOF) as a dual-modal sensor for sensitive detection and MRI imaging of OHP.
- To evaluate the stability, sensitivity, selectivity, and biocompatibility of the Mn-MOF platform for OHP detection.
Main Methods:
- Characterization of Mn-MOF structure, morphology, and properties using techniques like XRD, SEM, AFM, EDS, XPS, and DLS.
- Evaluation of Mn-MOF as a T1 MRI contrast agent and fluorescence sensor for OHP detection across various concentrations.
- In vitro and preliminary in vivo MRI experiments, along with cell viability and hemocompatibility assays.
Main Results:
- The Mn-MOF exhibited excellent stability over 28 days and demonstrated OHP-dependent T1 MRI signal attenuation.
- The fluorescence mode achieved a highly sensitive limit of detection (LOD) of 41.1 aM for OHP.
- Preliminary in vivo studies showed OHP-dependent signal changes in liver and kidney, with good hemocompatibility and cytocompatibility.
Conclusions:
- The developed Mn-MOF platform offers a promising dual-modal approach for integrating optical sensing and MRI readout for OHP.
- This strategy provides a foundation for advanced image-assisted evaluation of anticancer drugs in biological settings.
- The sensor's high sensitivity, selectivity, and biocompatibility support its potential clinical applications in chemotherapy management.
