[Current methods of systematic serological testing for infections in pregnant women in France]

Serological testing during pregnancy is an integral part of obstetric monitoring. This screening is essentially based on the detection and dosage of specific antibodies (IgM and IgG) of a virus, bacteria or parasite. Currently in France, 4 serologies are mandatory (toxoplasmosis, rubella, syphilis and hepatitis B) but others are recommended and systematically offered (HIV, HCV, CMV). Determination of immune status should ideally be done in the pre-conception period or as soon as possible after the diagnosis of pregnancy. In the absence of immunity (IgM-, IgG-), hygienic and dietary measures are recommended, and the monitoring methods vary with the pathogen concerned. If seroconversion is suspected (IgM+, IgG+), the patient must be referred to a specialized fetal medicine unit to discuss the need for additional testing and to begin treatment if necessary. If there is any doubt about the interpretation of the serology result, it is essential to refer the patient to a prenatal center or to seek advice from a national reference laboratory.