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Gold Nanoparticles-Embedded Mn/Zn-MOF with Enhanced Antioxidant Activities for Treating Atopic Dermatitis
Liping Dong1,2,3,4, Xinying Cai1,2,3,4, Ziying He1,2,3,4
1Department of Dermatology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China.
Small (Weinheim an Der Bergstrasse, Germany)
|July 13, 2026
Summary
A novel nanocomposite, Au@Mn/Zn-MOF (AMZM), effectively scavenges reactive oxygen species (ROS) to treat atopic dermatitis (AD). This multi-enzyme mimetic therapy shows promise in alleviating AD symptoms by restoring skin barrier function and reducing inflammation.
Area of Science:
- Biomaterials Science
- Nanotechnology
- Dermatology
Background:
- Atopic dermatitis (AD) involves impaired skin barrier function and immune dysregulation, with oxidative stress playing a key pathogenic role.
- Current AD treatments focus on immune and inflammatory pathways, often neglecting direct reactive oxygen species (ROS) clearance.
Purpose of the Study:
- To develop a multi-enzyme-mimetic nanocomposite for direct ROS scavenging to address oxidative stress in AD.
- To investigate the therapeutic potential of the Au@Mn/Zn bimetallic metal-organic framework (AMZM) for atopic dermatitis.
Main Methods:
- Construction of a multi-enzyme-mimetic nanocomposite (Au@Mn/Zn-MOF; AMZM) utilizing manganese and gold nanoparticles.
- Density functional theory (DFT) calculations to understand the electronic structure and catalytic activity of AMZM.
- In vitro cellular models and in vivo mouse models (DNCB-induced AD) to evaluate AMZM's efficacy.
Main Results:
- AMZM mimics superoxide dismutase (SOD) and catalase (CAT) activities, efficiently scavenging O2·− and H2O2.
- AMZM suppressed ROS, stabilized mitochondrial function, and downregulated inflammatory cytokines in cellular models.
- Topical AMZM application in AD mice significantly alleviated skin lesions, restored barrier function, and reduced immune infiltration, activating the FOXO3 pathway.
Conclusions:
- AMZM demonstrates significant antioxidant and anti-inflammatory effects through direct ROS scavenging and FOXO3 pathway activation.
- The developed nanocomposite presents a promising nanotherapeutic strategy for treating atopic dermatitis.
