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Updated: Jul 15, 2026
Production of Autologous Platelet-Rich Plasma for Boosting In Vitro Human Fibroblast Expansion
Published on: February 24, 2021
Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With
Xinhong Liang1,2, Xi Li2, Liujing Huang2
1Reproductive Medical Center The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China.
Background:
This meta-analysis evaluates the efficacy and safety of intrauterine autologous platelet-rich plasma (PRP) infusion in patients with recurrent implantation failure (RIF).
Methods:
Following PRISMA guidelines, we systematically searched major databases and included 10 randomized controlled trials (RCTs, n = 1 188). Study quality was assessed using the Cochrane RoB 2.0 tool.
Results:
PRP infusion significantly improved clinical pregnancy rate (RR = 2.23, 95% CI 1.84-2.69) and live birth rate (RR = 3.74, 95% CI 2.68-5.22) without increasing miscarriage risk. Subgroup analysis indicated that a 0.5 mL PRP volume was as effective as 0.5-1.0 mL, and a notably greater treatment effect was observed in blastocyst transfer cycles compared to cleavage-stage embryo transfers, suggesting potential enhanced benefit in this subgroup.
Conclusion:
Intrauterine PRP infusion is an effective and safe treatment for RIF. The findings on dose equivalence and differential efficacy by embryo stage offer valuable insights for optimizing clinical application.
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