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5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
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Published on: July 3, 2013

Delayed Diagnosis of Pulmonary-Renal Syndrome Presenting as Chronic Hemoptysis Leading to ESRD

Kalie Nuss1, Katiana Garagozlo2, Lilliana Barillas-Arias3

  • 1Department of Pediatrics, University of South Florida Morsani College of Medicine, Tampa, Florida, USA, usf.edu.

Case Reports in Pediatrics
|July 13, 2026
PubMed

Insights

This case highlights an unusual presentation of microscopic polyangiitis (MPA) in a child with chronic hemoptysis. Early recognition of diverse MPA symptoms is crucial for timely diagnosis and preventing severe outcomes like end-stage renal disease (ESRD).

Area of Science:

  • Pediatric Nephrology
  • Rheumatology
  • Clinical Case Reports

Background:

  • Microscopic polyangiitis (MPA) primarily affects the kidneys, often with varied symptoms.
  • Pulmonary involvement in MPA is less common and typically asymptomatic.
  • Recognizing diverse MPA presentations is vital for pediatric diagnosis.

Purpose of the Study:

  • To emphasize the importance of identifying varied MPA presentations in children.
  • To advocate for increased literature on MPA to improve diagnostic criteria.
  • To highlight a unique case of MPA presenting with chronic hemoptysis.

Main Methods:

  • Case report analysis.
  • Review of pediatric MPA literature.
  • Clinical diagnostic considerations.

Main Results:

  • An atypical pediatric MPA case presented with chronic hemoptysis as the primary symptom.
  • This unusual presentation delayed diagnosis and disease progression.
  • The patient developed end-stage renal disease (ESRD).

Conclusions:

  • Diverse MPA presentations, including atypical pulmonary symptoms like hemoptysis, must be considered in pediatric patients.
  • Further documentation and discussion of MPA cases are needed to refine diagnostic criteria.
  • Earlier diagnosis of pediatric MPA can prevent severe, life-long complications.

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