Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cytomegalovirus Disease

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

Automated Microbial Diagnostics

Automated Microbial Diagnostics

Automated diagnostic analyzers have transformed clinical microbiology by providing rapid and reliable methods for pathogen identification and antibiotic susceptibility testing. Among these systems, the Vitek 2 is widely used because it automates the traditionally labor-intensive processes of microbial identification (ID) and antibiotic susceptibility testing (AST), delivering standardized and timely results that are essential for effective patient care.Microbial Identification with ID CardsThe...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Late-Onset Sepsis in the Periviable Neonate.

Neonatal network : NN·2026

Same author

Atypical presentation of pyelonephritis in an infant.

BMJ case reports·2025

Same author

An unexpected case of neonatal compartment syndrome associated with congenital anomalies of kidney and urinary tract.

Case reports in perinatal medicine·2025

Same author

A Quality Improvement Project to Reduce Unplanned Extubations in the Neonatal Intensive Care Unit.

Advances in neonatal care : official journal of the National Association of Neonatal Nurses·2024

Same author

Ten-year review of neonatal neurosurgical outcomes and cost analysis.

Surgical neurology international·2023

Same author

Severe Anemia in the Newborn Nursery.

Clinical pediatrics·2019

Search research articles

Related Experiment Video

Updated: Jul 15, 2026

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

A Targeted Approach for Optimizing Congenital Cytomegalovirus (cCMV) Testing: A Quality Improvement Initiative.

Dean Howdeshell¹, Denise Kirsten, Colleen Nash

¹Author Affiliations: Division of Nursing, Rush University Medical Center, Chicago, Illinois (Howdeshell and Kirsten); Division of Infectious Diseases, Department of Pediatrics, Rush University Medical Center, Chicago, Illinois (Nash); and Division of Neonatology, Department of Pediatrics, Rush University Medical Center, Chicago, Illinois (Seske).

Advances in Neonatal Care : Official Journal of the National Association of Neonatal Nurses

|July 13, 2026

Summary

Implementing a standardized guideline for congenital cytomegalovirus (CMV) testing in neonates reduced unnecessary testing and improved consistency. The study found a low diagnostic yield in asymptomatic infants, suggesting a need for refined testing criteria.

Keywords:

clinical decision support systems congenital cytomegalovirus electronic health records intrauterine growth restriction neonatal intensive care unit quality improvement small for gestational age

More Related Videos

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

Published on: July 9, 2014

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Related Experiment Videos

Last Updated: Jul 15, 2026

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Automated Cell Enrichment of Cytomegalovirus-specific T cells for Clinical Applications using the Cytokine-capture System

Published on: October 5, 2015

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue

Published on: July 9, 2014

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Area of Science:

Neonatal Medicine
Infectious Diseases
Public Health

Background:

Congenital cytomegalovirus (CMV) is a common neonatal infection with inconsistent testing protocols.
Current testing practices lead to increased healthcare costs and low diagnostic yield.

Purpose of the Study:

To optimize resource utilization by reducing overtesting for congenital CMV.
To implement a standardized testing guideline for neonates classified as small for gestational age (SGA) or with intrauterine growth restriction (IUGR) in a NICU and GCN setting.

Main Methods:

An interprofessional team implemented a standardized congenital CMV testing guideline.
An electronic medical record-based best practice advisory (BPA) supported the guideline, with education for healthcare providers.
Weekly audits evaluated BPA-identified neonates over a 12-week period.

Main Results:

Forty-one neonates triggered the BPA; 24 underwent testing, with zero positive results.
A significant proportion of infants were tested for isolated IUGR/SGA without physical signs or additional risk factors.
Guideline adherence reached 90%.

Conclusions:

A standardized, risk-based congenital CMV testing guideline enhanced testing consistency.
The study demonstrated a low diagnostic yield in asymptomatic infants, supporting the need for refined testing criteria.
Further evaluation is required to assess the sustainability and refinement of testing criteria.