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Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
Microstructure-centric ultrasonic evaluation of granular composite oral solid dosage tablets
Tipu Sultan1, Vivek S Dave2, James Stephens3
1Photo-Acoustics Research Laboratory, Clarkson University, Department of Mechanical and Aerospace Engineering, Potsdam, NY 13699-5725, USA.
International Journal of Pharmaceutics
|July 13, 2026
Summary
This study introduces an ultrasonic method to characterize the microstructure and microviscoelasticity of Oral Solid Dosage (OSD) forms. The technique enables real-time release testing by analyzing wave dispersion and attenuation in pharmaceutical products.
Area of Science:
- Pharmaceutical Sciences
- Materials Science
- Acoustics
Background:
- Oral Solid Dosage (OSD) forms possess complex microstructures critical for quality attributes.
- Understanding microstructural mechanics and viscoelasticity is key to controlling drug release.
- Current models for ultrasonic wave propagation in granular media are limited.
Purpose of the Study:
- To develop a quantitative understanding of compact microstructure and microviscoelasticity in OSD forms.
- To establish a framework for characterizing granular media using ultrasonic elastic pulses.
- To enable non-destructive, real-time analysis of OSD properties.
Main Methods:
- Utilized high-frequency, short-wavelength ultrasonic elastic pulses.
- Developed a deterministic framework coupling Zener micro-viscoelasticity with Rayleigh scattering.
- Analyzed frequency-dependent longitudinal-wave attenuation and dispersion in OSD compacts.
Main Results:
- Demonstrated a novel ultrasonic methodology for microstructural and viscoelastic characterization.
- The framework successfully models granularity and viscoelastic losses.
- The method provides a non-destructive, volumetric probe of internal OSD properties.
Conclusions:
- The developed ultrasonic methodology is cost-effective, computationally efficient, and scalable.
- This approach supports rapid Real-Time Release Testing (RTRT) of OSD forms.
- The study advances the understanding of elastic wave propagation in viscoelastic granular media.
Keywords:
Compressed Oral Solid Dosage (OSD)Continuous Manufacturing (CM)Critical Quality Attributes (CQAs)Granular compositesMaterial Attributes (MAs)Microstructure-centric micro-viscoelastic characterizationProcess Analytical Technology (PAT)Process Parameters (PPs)Quality by Design (QbD)Real-Time Release Testing (RTRT)
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