Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 15, 2026

Measuring Motor Coordination in Mice
10:07

Measuring Motor Coordination in Mice

Published on: May 29, 2013

Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.

Manuel Ambrosone1,2,3, Elena Montagni4,5, Timothy J Buschman6,7

  • 1European Laboratory for Non-Linear Spectroscopy, Florence, Italy. ambrosone@lens.unifi.it.

Communications Biology
|July 13, 2026
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Internal state dynamically gates task-specific attractor dynamics in prefrontal cortex.

bioRxiv : the preprint server for biology·2026
Same author

Protracted Functional and Structural Reorganization of Human Prefrontal Cortex Supports Lateralized Category Geometries.

bioRxiv : the preprint server for biology·2026
Same author

Disrupted cortex-wide dynamics impair motor planning in Shank3-mutant mice.

bioRxiv : the preprint server for biology·2026
Same author

Building compositional tasks with shared neural subspaces.

Nature·2025
Same author

Reusable modular architecture enables flexible cognitive operations.

Research square·2025
Same author

A novel model of light-induced middle cerebral artery occlusion and recanalization in mice.

Communications biology·2025

Disruptions in SHANK3 gene function, a risk factor for autism spectrum disorder (ASD), impair preparatory brain activity for movement. This study reveals how altered cortical dynamics in Shank3b mutant mice contribute to motor planning deficits in ASD.

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Genetics

Background:

  • Coordinated cortical activity is crucial for voluntary movement planning.
  • Disruptions in this activity are linked to neurodevelopmental disorders, including autism spectrum disorder (ASD).
  • SHANK3 gene mutations are a significant risk factor for ASD, affecting synaptic and network function, but their precise impact on preparatory cortical dynamics is not fully understood.

Purpose of the Study:

  • To investigate the effects of Shank3 gene mutations on cortex-wide activity during motor planning.
  • To elucidate the neural mechanisms underlying motor deficits associated with SHANK3 mutations in ASD.

Main Methods:

  • Utilized wide-field calcium imaging in Shank3b+/- mice during spontaneous forepaw movements.

More Related Videos

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

Related Experiment Videos

Last Updated: Jul 15, 2026

Measuring Motor Coordination in Mice
10:07

Measuring Motor Coordination in Mice

Published on: May 29, 2013

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy
10:02

A Battery of Motor Tests in a Neonatal Mouse Model of Cerebral Palsy

Published on: November 3, 2016

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury
07:28

Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spinal Cord Injury

Published on: March 24, 2023

  • Integrated motion tracking and computational motif analysis to examine cortical activity patterns.
  • Assessed cortex-wide neural dynamics and their correlation with behavioral output.

    • Main Results:

    • Observed reduced correlation between cortical activity and behavior before movement onset in Shank3b+/- mice.
    • Found decreased expression of specific cortical motifs involving associative and motor areas.
    • Identified global functional hyperconnectivity and impaired motor planning capabilities.

    Conclusions:

    • Shank3b gene mutation disrupts spatiotemporal cortical dynamics crucial for motor planning.
    • Altered preparatory cortical processes in Shank3b mutant mice contribute to motor deficits observed in ASD.
    • Provides insights into the neural basis of ASD-related motor impairments.