Related Experiment Video
Updated: Jul 15, 2026
08:39
Generation of Electronic Cigarette Aerosol by a Third-Generation Machine-Vaping Device: Application to Toxicological Studies
Published on: August 25, 2018
Vaping-related lung disease: a narrative review
Christie Mellor1, Richard Davidson2, Benjamin Pippard1,2
1Department of Respiratory Medicine, Royal Victoria Infirmary, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK.
Journal of Thoracic Disease
|July 14, 2026
Summary
Vaping, or e-cigarette use, is linked to various lung conditions beyond EVALI, with long-term health impacts remaining unclear. Further research is vital for policy and public health guidance on vaping risks.
Area of Science:
- Pulmonology
- Public Health
- Toxicology
Background:
- Vaping device use has surged globally, especially among youth and young adults.
- While promoted for smoking cessation, vaping is increasingly associated with adverse pulmonary and extra-pulmonary effects.
- Long-term consequences of vaping on lung health are not well understood.
Purpose of the Study:
- To review current evidence on the pathophysiological effects of vaping on the lungs.
- To summarize clinical manifestations of vaping-related lung diseases.
- To provide an overview of vaping epidemiology and products.
Main Methods:
- A comprehensive literature search of PubMed was conducted up to January 2026.
- Keywords included 'Vaping', 'e-cigarette', 'lung injury', 'EVALI', 'pneumothorax', 'lung function', and 'epidemiology'.
- Inclusion criteria focused on English-language, peer-reviewed studies, supplemented by public policy resources.
Main Results:
- Vaping has surpassed traditional smoking in the UK, with significant uptake among never-smokers.
- Acute lung injury (EVALI) linked to vitamin E acetate has been identified, alongside other conditions like pneumothorax and hypersensitivity pneumonitis.
- Chronic respiratory symptoms are prevalent, but the long-term effects on lung function and chronic lung disease development are uncertain.
Conclusions:
- A spectrum of lung diseases is associated with vaping, not limited to EVALI.
- Vaping devices should not be considered safe due to emerging health risks.
- Continued research on long-term vaping impacts is essential for policy development and informed public health discussions.
Related Concept Videos
01:29Stimulants
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
01:20COPD: Pathogenesis and Clinical Features
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
01:23Chronic Obstructive Pulmonary Disease I: Introduction
Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
01:19Chronic Obstructive Pulmonary Disease IV: Clinical Manifestations
Chronic Obstructive Pulmonary Disease, or COPD, is a long-term condition marked by persistent and only partially reversible airflow limitation. It involves two overlapping conditions—chronic bronchitis and emphysema—which often co-appear but differ in dominant symptoms and underlying mechanisms.Chronic Bronchitis FeaturesChronic bronchitis presents with a persistent productive cough and thick, sometimes purulent mucus due to airway inflammation, enlarged mucus glands, and goblet cell...