Related Experiment Video
Updated: Jul 15, 2026

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation
Published on: February 26, 2013
Guidewire Ablation via Coronary Venous System for Frequent VPBs: A Case Report
Ling Jiang1, Jichun Liu1, Tao Ge1
1Department of Cardiology, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Insights
Guidewire ablation via the coronary venous system (CVS) effectively treats challenging ventricular arrhythmias from the left ventricular summit (LVS). This minimally invasive method resolves drug-refractory ventricular premature beats (VPBs) when conventional treatments fail.
Area of Science:
- Cardiology
- Electrophysiology
- Minimally Invasive Procedures
Background:
- Left ventricular summit (LVS) arrhythmias are difficult to treat with standard catheter ablation.
- Complex anatomy, coronary artery proximity, and epicardial fat hinder conventional approaches.
- Percutaneous guidewire ablation via the coronary venous system (CVS) offers a minimally invasive option.
Purpose of the Study:
- To present a case of successful guidewire ablation via the CVS for refractory ventricular premature beats (VPBs).
- To evaluate the efficacy and safety of this technique for LVS arrhythmias.
- To highlight its potential as an alternative to conventional methods.
Main Methods:
- Guidewire ablation performed via the coronary venous system (CVS).
- Precise mapping and individualized parameter settings were utilized.
- Strict safety monitoring was implemented throughout the procedure.
Main Results:
- Successful elimination of symptomatic, frequent ventricular premature beats (VPBs) in a 60-year-old female patient.
- Complete resolution of palpitations without procedure-related complications.
- No recurrence of VPBs during follow-up, with preserved left ventricular function.
Conclusions:
- Percutaneous guidewire ablation via the CVS is effective for drug-refractory VPBs from the LVS.
- This technique serves as a viable complementary option for complex ventricular arrhythmias.
- It offers a feasible therapeutic strategy when traditional ablation methods are unsuccessful.
Background:
Ventricular arrhythmias originating from the left ventricular summit (LVS) are challenging to treat with conventional catheter ablation due to the region's complex anatomy, proximity to coronary arteries, and epicardial fat coverage. Percutaneous guidewire ablation via the coronary venous system (CVS) provides a minimally invasive therapeutic option for refractory arrhythmias in this area.
Case Presentation:
Herein, we present the case of a 60-year-old Asian female patient who had a 1-year history of palpitations and was diagnosed with symptomatic, frequent ventricular premature beats (VPBs). The patient exhibited an inadequate response to metoprolol and amiodarone as pharmacological therapy and conventional ablation approaches. Following guidewire ablation via the CVS, the VPBs were eliminated entirely, her palpitations fully resolved, and no procedure-related complications, such as coronary artery injury or thrombosis, were observed. During follow-up, there was no recurrence of VPBs, and left ventricular function remained normal.
Conclusion:
By employing precise mapping, individualized parameter settings, and strict safety monitoring, percutaneous guidewire ablation via the CVS can effectively treat drug-refractory VPBs originating from the LVS. Importantly, this approach could serve as a complementary option when traditional ablation methods are unsuccessful, offering a feasible therapeutic strategy for complex ventricular arrhythmias.
Related Concept Videos
Cardiac Catheterization IV: Nursing Management
Cardiac Catheterization II: Right Heart Catheterization

