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Updated: Jul 15, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

Understanding the cellular architecture of Huntington's disease.

Dorian Pustina¹

¹CHDI Management, Inc, Princeton, United States.

|July 14, 2026

Summary

A new diffusion MRI technique reveals cellular changes in the basal ganglia, offering insights into Huntington's disease progression. This method helps visualize the brain

Area of Science:

Neuroimaging
Neuroscience
Biomedical Engineering

Background:

Huntington's disease is a neurodegenerative disorder affecting the basal ganglia.
Understanding cellular anomalies is crucial for tracking disease progression.

Purpose of the Study:

To introduce a novel diffusion MRI method for visualizing cellular architecture.
To investigate basal ganglia degeneration in Huntington's disease at a cellular level.

Main Methods:

Development of an advanced diffusion MRI sequence.
Application of the technique to study basal ganglia in Huntington's disease models or patients.

Main Results:

The diffusion MRI approach successfully visualized anomalies in cellular architecture.

Keywords:

Huntington's Imaging Neurite Density human neurodegeneration neuroscience

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Last Updated: Jul 15, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species

Published on: February 27, 2018

Microtubule Plus-End Dynamics Visualization in Huntington's Disease Model based on Human Primary Skin Fibroblasts

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Published on: January 8, 2022

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Efficient and Scalable Production of Full-length Human Huntingtin Variants in Mammalian Cells using a Transient Expression System

Published on: December 10, 2021

Specific changes in the basal ganglia indicative of degeneration were identified.

Conclusions:

This new diffusion MRI technique provides unprecedented insights into the cellular basis of Huntington's disease.
The findings pave the way for improved diagnostic and monitoring tools for neurodegenerative disorders.