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Updated: Jul 15, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
Anticancer activity of amide and ester derivatives of the ent-labdane 2α-hydroxyeperuic acid obtained via
Francisco Juárez-Carrillo1, Julio C Ontiveros-Rodríguez2, Mónica Luna-Vázquez1
1Instituto de Investigaciones Químico Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Edificio B-1, Ciudad Universitaria, Morelia, Michoacán, Mexico.
Abstract:
Medicinal plants are an invaluable source of specialized metabolites with unique and complex chemical structures. This chemical diversity offers a rich resource for discovering new compounds with therapeutic potential. One notable example is Ageratina petiolaris, which produces a mixture of esters of 2α-hydroxyeperuic acid (1) in high quantity. The ent-labdane 2, a product of the alkaline hydrolysis of 1, possesses a chemical structure with promising therapeutic potential. In this work, aniline, cyclohexylamine, 4-chloroaniline, bencilamine, p-cinnamyl alcohol, phenol, 4-bromophenol, and 4-methoxyphenol were used to prepare ester and amide derivatives of 2 in a one-pot process aided with sonochemistry, yielding the respective compounds in moderate to good yields. Additionally, the antiproliferative potential of the amides and esters was tested in vitro against MCF-7, HeLa, A549, and K562 cancer cell lines. The results showed significant cytotoxic activity for almost all the evaluated derivatives, making them promising candidates for potential therapeutic agents against certain types of cancer.
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