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Related Experiment Video

Updated: Jul 16, 2026

Biofunctionalization of Magnetic Nanomaterials
06:40

Biofunctionalization of Magnetic Nanomaterials

Published on: July 16, 2020

Engineering calcium-based nanoparticles for cancer treatment.

Matilde Costa1, Beatriz Carvalho2, Ângela Sousa1

  • 1RISE-Health UBI, University of Beira Interior, Avenida Infante D. Henrique, Covilhã 6200-506, Portugal.

Colloids and Surfaces. B, Biointerfaces
|July 14, 2026
PubMed
Summary

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Calcium-based nanoparticles show promise in cancer therapy. Their unique properties enable targeted drug delivery, gene therapy, and immunotherapy, offering new hope for oncology treatments.

Area of Science:

  • Nanomedicine and Materials Science
  • Biomedical Engineering
  • Oncology

Background:

  • Calcium-based nanoparticles exhibit excellent biocompatibility and biodegradability.
  • They offer versatile physicochemical properties for diverse biomedical applications.
  • Various calcium compounds like calcium phosphate and hydroxyapatite are utilized.

Purpose of the Study:

  • To review advancements in calcium-based nanoparticles for cancer treatment.
  • To highlight their synthesis, cellular interactions, and therapeutic potential.
  • To discuss their role in drug delivery, gene therapy, and immunotherapy.

Main Methods:

  • Synthesis via wet and dry-based methods for controlled particle characteristics.
  • Surface functionalization with targeting ligands (antibodies, peptides, aptamers).
Keywords:
Calcium-based NanoparticlesCancer treatmentDrug delivery

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  • Investigation of cellular apoptosis induction via calcium overload.

    • Main Results:

    • Calcium nanoparticles effectively modulate the tumor microenvironment.
    • Targeted delivery and enhanced therapeutic efficacy are achieved.
    • Surface modifications improve specificity and reduce off-target effects.

    Conclusions:

    • Calcium-based nanoparticles are multifunctional and safe tools in oncology.
    • They hold significant potential for diagnostics and therapeutics in cancer treatment.
    • Further research into clinical prospects is warranted.