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Design, synthesis and structure-activity relationship analysis of bufalin as antitumor agents
Yao-Chen Wu1, Min-Hui Chen1, Meng-Yuan Zhang1
1National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, Jiangsu 210023, China.
None:
Two series of bufalin derivatives including three compounds were designed, synthesized, and evaluated for their antiproliferative activity against A549 (non-small cell lung cancer) and HeLa (cervical cancer) cells. Structure-activity relationship (SAR) analysis revealed that methylation of the C3β-hydroxy group or replacement of the C17 six-membered unsaturated lactone ring with a five-membered lactone ring reduced the antitumor activity. These findings indicate that both the C3β-OH group and the intact C17 lactone moiety are essential pharmacophoric elements for the antitumor activity of bufalin.
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