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Related Experiment Video

Updated: Jul 16, 2026

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
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Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example

Published on: October 24, 2012

Intracranial mapping identifies high-frequency cortical dynamics underlying visual discomfort.

Lenka Pánková Jurkovičová1, Robert Roman1, Jan Cimbálník2

  • 1Brno Epilepsy Center, Department of Neurology, Faculty of Medicine, Masaryk University and St. Anne's University Hospital, Brno, Czech Republic; Member of European Reference Network (ERN)-EpiCARE; CEITEC - Central European Institute of Technology, Masaryk University, Brno, Czech Republic.

Neuroimage
|July 14, 2026
PubMed
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High-contrast patterns cause visual discomfort by increasing high-frequency brain activity in extrastriate visual cortex (BA 18/V2). This heightened neural response correlates with individual sensitivity, suggesting a network dynamics basis for visual discomfort.

Area of Science:

  • Neuroscience
  • Visual Perception
  • Epilepsy Research

Background:

  • High-contrast patterns induce visual discomfort and perceptual distortions.
  • This sensitivity is linked to cortical hyperexcitability and altered neural responses.
  • Previous research focused on gamma-band oscillations, with limited investigation into higher frequencies and network interactions.

Purpose of the Study:

  • Investigate the neural correlates of visual discomfort.
  • Examine high-frequency local field potential activity in response to aversive visual stimuli.
  • Explore large-scale network interactions in visual discomfort.

Main Methods:

  • Used intracranial EEG recordings from epilepsy patients.
  • Analyzed local field potential activity (55-1000 Hz) in visual and higher-order brain regions.
Keywords:
cortical excitabilityhigh-frequency activityintracranial EEGneural dynamicspattern glare testvisual discomfort

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Last Updated: Jul 16, 2026

Mapping Cortical Dynamics Using Simultaneous MEG/EEG and Anatomically-constrained Minimum-norm Estimates: an Auditory Attention Example
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  • Correlated frequency-specific power changes with self-reported visual discomfort.

    • Main Results:

    • Aversive patterns increased high-gamma power in extrastriate cortex (BA 18/19), not primary visual cortex (BA 17).
    • Higher visual discomfort correlated with stronger, sustained high-frequency activity in BA 18.
    • Aversive stimuli also engaged temporal regions, with ripple-band activity mirroring high-gamma patterns.

    Conclusions:

    • Visual discomfort reflects individual differences in extrastriate cortical excitability.
    • Frequency-specific network dynamics underlie susceptibility to aversive visual stimuli.
    • High-frequency activity in BA 18/V2 is a potential neural correlate of visual discomfort.