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Updated: Jul 16, 2026

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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The Novel HLA-C*01:303 Allele, Identified in a Living Liver Donor of Canadian Dutch Descendent

Abubaker M E Sidahmed1, A Sharma1, L Chen1

  • 1Immunogenetics and Transplantation Laboratory, London Health Sciences Centre and Pathology and Laboratory Medicine, University Hospital, London, Ontario, Canada.

HLA
|July 14, 2026
PubMed

Insights

A new Human Leukocyte Antigen-C (HLA-C) allele, HLA-C*01:303, was discovered in a Canadian donor. This finding utilized advanced next-generation sequencing technology for precise identification.

Area of Science:

  • Immunogenetics
  • Molecular biology

Background:

  • Human Leukocyte Antigen (HLA) genes are crucial for immune response.
  • Allelic variations within HLA genes contribute to immune system diversity and disease susceptibility.

Purpose of the Study:

  • To report the identification and characterization of a novel HLA-C allele.

Main Methods:

  • Next-generation sequencing (NGS) was employed for high-resolution genetic analysis.
  • The study involved a Canadian donor of Dutch descent.

Main Results:

  • A novel HLA-C allele, designated HLA-C*01:303, was identified.
  • The allele was discovered in an individual with Dutch ancestry.

Conclusions:

  • The discovery of HLA-C*01:303 expands the known HLA-C allele repertoire.
  • This finding contributes to the understanding of HLA polymorphism in diverse populations.

Keywords:
HLA polymorphismHLA‐C genealleleshaplotypeshistocompatibility testing

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