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Orthotopic Left Lung Transplantation in Rats

Orthotopic Left Lung Transplantation in Rats

Published on: July 3, 2025

Current state of evidence for RATS lobectomy for NSCLC.

Geraud Galvaing¹, Nicolas d'Ostrevy², Jean-Baptiste Chadeyras³

¹Department of Thoracic and Endocrine Surgery, Jean Perrin Cancer Center, 58 rue Montalembert, Clermont-Ferrand, 63000, France. geraud.galvaing@clermont.unicancer.fr.

Journal of Cardiothoracic Surgery

|July 15, 2026

Summary

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Robot-assisted thoracic surgery (RATS) for non-small cell lung cancer (NSCLC) lobectomy is safe and effective, with outcomes comparable to traditional methods. Further research is needed to confirm definitive clinical superiority and cost-effectiveness.

Area of Science:

Thoracic Surgery
Surgical Oncology
Minimally Invasive Surgery

Background:

Robot-assisted thoracic surgery (RATS) is increasingly used for non-small cell lung cancer (NSCLC) pulmonary lobectomy.
Video-assisted thoracic surgery (VATS) is the established minimally invasive standard, but the benefits of robotic platforms are debated.

Purpose of the Study:

To review and critically analyze the literature comparing RATS lobectomy for NSCLC with VATS and open surgery.
To evaluate oncological outcomes, lymph node assessment, perioperative results, technical aspects, learning curve, and economic implications.

Main Methods:

Narrative review of existing literature.
Focus on comparative data from retrospective studies and database analyses.

Keywords:

Lobectomy Lung cancer RATS Surgery Thoracotomy VATS

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Main Results:

RATS lobectomy is feasible and safe in experienced centers, with oncological outcomes comparable to VATS and open surgery.
Perioperative outcomes are generally similar, though RATS may offer more extensive lymph node assessment.
Higher costs for RATS are a concern, influenced by institutional volume and resource allocation.

Conclusions:

RATS lobectomy is a viable minimally invasive option for selected NSCLC patients, providing comparable outcomes to established techniques.
Technical advantages exist, but definitive clinical superiority is not yet proven.
Further prospective studies and standardized reporting are necessary.