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Related Experiment Videos

Association Between ER/PR-Positive Breast Tumors and Digestive Cancers.

Anca Andreea Nica1,2, Traian Pătrașcu2,3, Vlad Denis Constantin1,2

  • 1Department of General Surgery, Sfântul Pantelimon Emergency Clinical Hospital, Sos Pantelimon nr 340-342, 021659 Bucharest, Romania.

Diagnostics (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

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Women with hormone receptor-positive breast cancer may have more gastrointestinal lesions. Endoscopic monitoring could aid early detection of digestive cancers in these patients.

Area of Science:

  • Oncology
  • Gastroenterology

Background:

  • Breast cancer is the most common female malignancy, with ER/PR-positive tumors being the majority.
  • Increased survival rates highlight concerns about secondary malignancies, including gastrointestinal (GI) neoplasia.
  • Emerging evidence suggests a link between breast cancer and GI issues.

Purpose of the Study:

  • To evaluate endoscopic monitoring (colonoscopy and upper GI endoscopy) in ER/PR-positive breast cancer patients.
  • To assess the potential for early detection of digestive lesions in this population.
  • To identify associations between breast cancer and GI neoplasia.

Main Methods:

  • Prospective observational study of 186 female patients with ER/PR-positive breast cancer.
  • 95 patients underwent colonoscopy; 91 underwent upper GI endoscopy.
Keywords:
ER/PR-positivebreast cancerdigestive tumors

Related Experiment Videos

  • Data collected included clinical factors, demographics, GI symptoms (questionnaire), and endoscopic/histopathological findings.

    • Main Results:

    • Colonoscopy revealed polyps and lesions, primarily in the rectum and descending colon; 1 malignant and 2 borderline lesions were found via biopsy.
    • Upper GI endoscopy most frequently showed gastritis, followed by ulcers and polyps; most results were normal.
    • 72% of patients had risk factors for digestive malignancy; most reported improved GI symptoms post-treatment.

    Conclusions:

    • ER/PR-positive breast cancer patients may have a higher prevalence of GI lesions, possibly due to shared risk factors or endocrine therapy effects.
    • Symptom-oriented endoscopic evaluation can aid early detection of premalignant and malignant GI conditions.
    • A multidisciplinary, risk-adapted surveillance approach is recommended; further large-scale studies are needed for evidence-based screening.