Related Experiment Video
Updated: Jul 16, 2026

Design and Construction of a Cost Effective Headstage for Simultaneous Neural Stimulation and Recording in the Water Maze
Published on: October 13, 2010
Design and Measured Assessment of a MOS-Only, Capacitorless, Miniature 64-Channel Headstage Circuit for High-Density
Simos Koutsoftidis1, Georgios Gryparis1, Maciej Zajaczkowski1
1The Department of Bioengineering, Imperial College London, London SW7 2AZ, UK.
Background:
We present a miniature (30 × 34 mm) 64-channel data acquisition headstage optimized for high-density surface electromyography.
Methods:
The headstage is made up of a multi-channel ASIC analogue front-end utilizing only MOS transistors, fabricated in 350 nm CMOS technology (IC die dimensions 6.9 × 1.8 mm), combined with an off-the-shelf multi-channel current-input ADC (DDC264, Texas Instruments). The ASIC analogue front-end employs MOS-based capacitors for both processing and AC-coupling.
Results:
The combination of these two sub-circuits enables the simultaneous recording of 64 channels at a typical sampling rate of 4 KHz with a maximum analogue bandwidth of 0.5-1500 Hz and a resolution of 20-bits. Typical input-referred-noise, determined by the analogue front-end, is 3.5 μVRMS for a surface EMG bandwidth of interest of 20-500 Hz. This two-chip solution results in a power consumption of 5 mW per channel. Analogue performance variability of the custom ASIC was characterized across a dataset of 960-channels (15 dies) from two fabrication runs.
Conclusions:
This work practically demonstrates the viability of using both a MOS-only analogue front-end and commercially available off-shelf high-performance back-end hardware already developed for medical imaging applications to record high-density surface biosignals. The aforementioned techniques can be employed to reduce the size and cost for systems or wearable devices; facilitating the translation of high-density bio-acquisition setups from the research environment to more affordable commercial products.
More Related Videos
08:43Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning
Published on: October 22, 2015
05:26Low-Cost Electroencephalographic Recording System Combined with a Millimeter-Sized Coil to Transcranially Stimulate the Mouse Brain In Vivo
Published on: May 26, 2023