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Biopolymer-Based 3D Printing for Dental-Pulp Complex Tissue Regeneration: Innovations and Challenges.

Loredana Corina Toderici¹, Claudia Nicoleta Feurdean¹, Alexandrina Muntean²

¹Department of Oral Rehabilitation, Faculty of Dentistry, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania.

Molecules (Basel, Switzerland)

|July 15, 2026

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Three-dimensional (3D) bioprinting shows promise for regenerating the dentin-pulp complex, overcoming limitations of conventional treatments by creating functional biomimetic scaffolds using advanced biomaterials and stem cells.

Area of Science:

Biomaterials Science
Regenerative Medicine
Dental Tissue Engineering

Background:

Conventional endodontic treatments fail to restore the biological function of the dentin-pulp complex.
Regenerative endodontics aims to restore pulp tissue vitality and function.
Three-dimensional (3D) printing and bioprinting offer novel approaches to dental tissue engineering.

Purpose of the Study:

To review advances in bioprinting technologies for pulp regeneration.
To explore biomaterials, bioinks, and stem cell sources used in pulp regeneration.
To examine the influence of the 3D microenvironment on regenerative outcomes.

Main Methods:

Literature review of current advances in bioprinting for dentin-pulp complex regeneration.

Keywords:

3D printing bioink biopolymers pulp regeneration regenerative dentistry scaffolds tissue engineering

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Synthesis of information on biomaterials, bioinks, stem cells, and scaffold properties.

Analysis of the impact of the 3D microenvironment on cell behavior and tissue formation.

Main Results:

Bioprinting enables fabrication of biomimetic scaffolds with controlled properties.
Scaffold composition, mechanical properties, and architecture influence cell viability, differentiation, angiogenesis, and neurogenesis.
Various stem cell sources and bioinks are being explored for pulp regeneration.

Conclusions:

Bioprinting holds significant potential for dentin-pulp complex reconstruction.
Challenges remain in bioink optimization, vascular integration, and long-term validation.
Multidisciplinary approaches are needed for clinical translation of bioprinting strategies.