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Nano-Enabled Advances in Tea Tree Essential Oil (Melaleuca alternifolia): Composition, Bioactivity, and Emerging

Huy Loc Nguyen1, Hong Minh Xuan Nguyen2, Thi Bich Ngoc Nguyen3

  • 1Department of Engineering and Technology, Van Hien University, Ho Chi Minh City 72508, Vietnam.

Materials (Basel, Switzerland)
|July 15, 2026
PubMed
Summary

Tea tree essential oil (TTO) shows broad-spectrum antimicrobial activity for food preservation. Nanoformulations enhance TTO

Keywords:
antimicrobialencapsulationfood safetynanoemulsionstea tree oilterpinen-4-ol

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Area of Science:

  • Food Science
  • Microbiology
  • Nanotechnology

Background:

  • Tea tree essential oil (TTO) from Melaleuca alternifolia possesses broad-spectrum antimicrobial properties due to terpene content.
  • Its efficacy against foodborne pathogens is linked to interactions with microbial membranes and intracellular targets.

Purpose of the Study:

  • To comprehensively analyze TTO as a sustainable antimicrobial for food preservation.
  • To evaluate physicochemical properties, antimicrobial mechanisms, and nanoformulations for enhanced efficacy.

Main Methods:

  • Review of TTO's chemical composition, physicochemical properties, and antimicrobial mechanisms.
  • Assessment of nanostructured delivery systems (nanoemulsions, encapsulants, nanocomposites).
  • Evaluation of TTO nanoformulations in edible coatings, active packaging, and sanitation protocols.

Main Results:

  • TTO's effectiveness is influenced by composition, hydrophobicity, solubility, and stability.
  • Nanodelivery systems improve TTO's stability, release, and antimicrobial potency.
  • TTO nanoformulations show promise in fresh produce, meat, and dairy applications.

Conclusions:

  • TTO-based nanoformulations offer a scalable approach for next-generation food preservation.
  • Further research is needed to address limitations like volatility, sensory issues, and regulatory hurdles for commercialization.