Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

Hemorrhagic Stroke ll: Pathophysiology

Hemorrhagic Stroke ll: Pathophysiology

A hemorrhagic stroke develops when a cerebral blood vessel ruptures, allowing blood to escape into the surrounding brain tissue, as in intracerebral hemorrhage (ICH), or into the subarachnoid space, as in subarachnoid hemorrhage (SAH). Because the skull is a rigid compartment, the sudden presence of extravascular blood rapidly increases intracranial pressure and compresses adjacent neural structures, leading to immediate tissue injury and impaired cerebral perfusion.Mass Effect and Primary...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Hemorrhagic Stroke l: Introduction

Hemorrhagic Stroke l: Introduction

A hemorrhagic stroke is an acute neurological event that occurs when a weakened cerebral blood vessel ruptures, allowing blood to accumulate within or around the brain. The sudden release of blood forms a focal hematoma that increases intracranial pressure, displaces neural tissue, and can obstruct cerebrospinal fluid pathways. These effects may be compounded by intraventricular extension of the hemorrhage, cerebral edema, or compression of adjacent structures, all of which contribute to...

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A Blood-Triggered Adhesive Hydrogel Loaded with Reactive Oxygen Species-Responsive Liposomes for the Treatment of Acute Kidney Injury.

ACS nano·2026

Same author

A T-Cell Epitope Tandem Peptide Designed from Two Major Allergens of <i>Crassostrea angulata</i> Shows Potential for Inducing Dual Immune Tolerance.

Journal of agricultural and food chemistry·2026

Same author

A universal brown dwarf desert formed between planets and stars.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Designing a Hypoallergenic Mutant of Cra a 2 with T-Cell Reactivity.

Journal of agricultural and food chemistry·2026

Same author

A fast powerful X-ray transient from possible tidal disruption of a white dwarf.

Science bulletin·2026

Same author

Equation of State of Decompressed Quark Matter, and Observational Signatures of Quark-Star Mergers.

Physical review letters·2025

Search research articles

Related Experiment Video

Updated: Jul 16, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Coagulation Activation Markers Associate with Early Neurological Function and Infarct Volume in Acute Ischemic

Xiaolin Lu¹, Weiwei Wang^2,3, Yangchao Xie⁴

¹Department of Neurology, the Second Affiliated Hospital of Xiamen Medical College, Xiamen, People's Republic of China.

International Journal of General Medicine

|July 15, 2026

Summary

Elevated levels of thrombin-antithrombin complex (TAT), tissue plasminogen activator-inhibitor complex (t-PAIC), and D-dimer predict acute ischemic stroke severity. These markers, combined with imaging, can aid clinical decisions for better patient outcomes.

Keywords:

acute ischemic stroke coagulation activation markers thrombin-antithrombin complex tissue prothrombin activator-prothrombin activator inhibitor complex

More Related Videos

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

Related Experiment Videos

Last Updated: Jul 16, 2026

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

A Fibrin-Enriched and tPA-Sensitive Photothrombotic Stroke Model

Published on: June 4, 2021

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Modeling Stroke in Mice: Permanent Coagulation of the Distal Middle Cerebral Artery

Published on: July 31, 2014

Area of Science:

Neurology
Hematology
Cardiovascular Research

Background:

The coagulation-fibrinolysis system is crucial in thrombosis.
Its role in guiding early revascularization for ischemic stroke is not fully understood.

Purpose of the Study:

To investigate the link between coagulation activation markers and neurological function in acute ischemic stroke (AIS).
To assess the predictive value of these markers for stroke severity and infarct volume.

Main Methods:

Retrospective cohort study of 135 acute ischemic stroke patients.
Stratified patients into mild (NIHSS≤3) and moderate-to-severe (NIHSS>3) stroke groups.
Quantified five coagulation markers: thrombomodulin (TM), thrombin-antithrombin complex (TAT), plasmin-α2 plasmin inhibitor complex (PIC), tissue plasminogen activator-inhibitor complex (t-PAIC), and D-dimer.

Main Results:

TAT, t-PAIC, and D-dimer levels were significantly higher in moderate-to-severe stroke patients.
D-dimer was an independent predictor of stroke severity (OR=1.002).
TAT and D-dimer correlated positively with infarct volume, particularly in the anterior circulation.

Conclusions:

TAT, t-PAIC, and D-dimer can predict acute ischemic stroke severity.
These markers offer a simple, rapid auxiliary tool for clinical decision-making when combined with imaging.