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Related Concept Videos

Local Anesthetics: Differential Sensitivity of Nerve Fibers01:24

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Updated: Jul 17, 2026

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing
07:13

Implantation and Control of Wireless, Battery-free Systems for Peripheral Nerve Interfacing

Published on: October 20, 2021

Peripheral Low Frequency Versus High Frequency Nerve Stimulation: A Case Series.

Alvise Martini1, Felice Occhigrossi2, Vittorio Schweiger1

  • 1Department of Anesthesiology and Pain Medicine, University of Verona, Verona, Italian Republic.

Pain Medicine Case Reports
|July 15, 2026
PubMed
Summary

High-frequency peripheral nerve stimulation (PNS) may offer superior pain relief for certain neuropathic pain conditions compared to low-frequency therapy. This approach shows promise for patients with Complex Regional Pain Syndrome Type II who have not responded to lower frequencies.

Area of Science:

  • Neurology
  • Pain Management
  • Biomedical Engineering

Background:

  • Peripheral nerve stimulation (PNS) is a viable treatment for chronic neuropathic pain.
Keywords:
CRPSChronic painComplex Regional Pain Syndromecase seriesperipheral nerve stimulation

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  • Identifying the specific nerve responsible for pain guides the implantation of a PNS device.
  • Electrical impulses from PNS disrupt pain signals, providing pain relief.