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Topical Sirolimus Therapy for Agminated Pyogenic Granulomas: A Two-Case Report
Stetson Van Matre1, Evan Hicks1, Gresham T Richter1,2
1Department of Otolaryngology-Head and Neck Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Pediatric Dermatology
|July 15, 2026
Summary
Topical sirolimus shows promise for treating agminated pyogenic granulomas (PGs). This mTOR inhibitor effectively reduced size, color, and bleeding in two patients with this challenging vascular tumor.
Area of Science:
- Dermatology
- Vascular Biology
- Oncology
Background:
- Pyogenic granulomas (PGs) are benign vascular tumors.
- Agminated PGs present unique treatment challenges.
- Existing treatments for PGs include excision, laser, cryotherapy, topical imiquimod, and topical timolol.
