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Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
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Mechanical Ventilation III: Noninvasive Ventilation

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Mechanical Ventilation II: Invasive Ventilation

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Respiratory Depth
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Related Experiment Video

Updated: Jul 17, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

A Novel Method for Predicting Recirculation by Sweep-Gas Control in Extracorporeal Membrane Oxygenation.

Tomoki Tahara¹, Daisuke Sakota², Nobutomo Morita³

¹Department of Cardiovascular Surgery, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Annals of Thoracic and Cardiovascular Surgery : Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

|July 15, 2026

Summary

A new method uses temporary sweep-gas control to quickly estimate recirculation in veno-venous extracorporeal membrane oxygenation (VV ECMO). This technique offers a less invasive way to monitor and optimize VV ECMO patient care.

Keywords:

cardiopulmonary bypass extracorporeal membrane oxygenation hemodynamics medical devices recirculation

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Published on: January 17, 2025

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Last Updated: Jul 17, 2026

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Veno-Venous Extracorporeal Membrane Oxygenation in a Mouse

Published on: October 24, 2018

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Point-of-Care Ultrasound for Peripheral Veno-Arterial Extracorporeal Membrane Oxygenation Without Left Ventricular Venting

Published on: January 17, 2025

Area of Science:

Cardiovascular Sciences
Biomedical Engineering
Critical Care Medicine

Background:

Recirculation is a significant challenge in veno-venous extracorporeal membrane oxygenation (VV ECMO), potentially impacting treatment efficacy.
Accurate and timely assessment of recirculation is crucial for effective VV ECMO management.

Purpose of the Study:

To introduce and validate a novel method for estimating the recirculation ratio in VV ECMO circuits.
To utilize temporary sweep-gas control for a rapid and less invasive recirculation assessment.

Main Methods:

A simulated VV ECMO circuit was used to measure recirculation flow by introducing a short circuit.
Temporary sweep-gas cessation induced measurable changes in oxygen saturation (SpreO2 and SpostO2).
The ratio of temporal oxygen saturation changes (ΔSpreO2/ΔSpostO2) was correlated with the recirculation ratio and validated in a porcine model.

Main Results:

Circuit experiments showed a relative prediction error of 7.0% ± 5.2% for the recirculation ratio.
In vivo porcine model experiments yielded a prediction error of 7.5% ± 4.0%.
Early prediction times varied based on recirculation levels, ranging from approximately 3-4 seconds in circuits to 10-28 seconds in animal models.

Conclusions:

The proposed sweep-gas control method provides a rapid and less invasive approach to predict recirculation ratios in VV ECMO.
This technique holds potential as a practical tool for optimizing VV ECMO management and patient outcomes.