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Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
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First-order field autocorrelation function analysis-based dynamic OCT for tissue viability assessment.

Wei Chen1, Jinze Zhang2, Lingxuan Meng1

  • 1Department of Biomedical Engineering, Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China.

Biomedical Optics Express
|July 16, 2026
PubMed
Summary

This study presents g1-dynamic optical coherence tomography (g1-dOCT) for assessing tissue viability. This new method offers stable, intuitive imaging for long-term drug screening and tissue dynamics evaluation.

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Area of Science:

  • Biomedical Optics
  • Tissue Engineering
  • Pharmacology

Background:

  • Long-term tissue viability assessment is crucial for drug screening.
  • Current methods often require complex post-processing or lack stability.
  • High-throughput screening demands efficient and reliable longitudinal evaluation tools.

Purpose of the Study:

  • Introduce g1-dynamic optical coherence tomography (g1-dOCT) for robust tissue viability assessment.
  • Develop a dynamic index (Id) for intuitive, semi-quantitative analysis of tissue activity.
  • Establish g1-dOCT as a reliable tool for longitudinal studies in pharmacological screening.

Main Methods:

  • Derivation of a dynamic index (Id) from the first-order field autocorrelation function.
  • Encoding activity intensity directly as image brightness for intuitive interpretation.
  • Application of g1-dOCT to tumor slices during chemotherapy and dynamic hepatocyte apoptosis models.

Main Results:

  • Demonstrated stability of the dynamic index (Id) across varying imaging conditions.
  • Showcased consistent performance of g1-dOCT over extended time courses (46 hours).
  • Validated the method's suitability for high-throughput settings, including 3D tissue constructs in 48-well plates.

Conclusions:

  • g1-dOCT provides a stable and interpretable method for longitudinal tissue dynamics evaluation.
  • The technique is well-suited for large-scale drug screening and pharmacological studies.
  • g1-dOCT offers a reliable tool for assessing tissue viability and response to treatment over time.