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Updated: Jul 17, 2026

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Two undescribed bisabolane-type sesquiterpenoids from the endophytic fungus Penicillium herquei
Yi-Yang Xiong1,2, Lin-Lin Li1,2, Jing Huang1,2
1School of Life Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China.
Abstract:
Sixteen compounds, including two undescribed bisabolane-type sesquiterpenoids (1, 2), four aromatic derivatives (3-6), two cyclopeptides (7, 8), two acyclic sesquiterpenes (9-10), four fatty acid esters (11-14) and two fatty acids (15-16), were separated from the endophytic fungus Penicillium herquei. Their structures were established by analysis of spectroscopic data, HRESIMS spectra, NMR data and comparison with data in relevant literature. It is the first time that all of these compounds were isolated from P. herquei. The in vitro cytotoxicity of all isolated was evaluated against four tumor cell lines (HCT116, A549, HeLa, and Hepg2 cells) by the MTT assay, and compounds 1, 2, 4, 7 and 8 exhibited cytotoxicity with IC50 values ranging from 9.7 ± 0.8 to 37.4 ± 2.5 μM.
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