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Fatal adverse reactions to injectable ceftriaxone sodium in Syrian Arab Republic
Abeer Srour1, Basima Arous1, Mohammad Amer Al-Mardini1
1Department of Pharmaceutical Chemistry and Quality Control, Faculty of Pharmacy, Damascus University, Damascus, Syrian Arab Republic.
Background:
Reports of fatal adverse reactions to ceftriaxone sodium have raised serious safety concerns in Syrian Arab Republic, yet evidence describing fatal outcomes remains limited.
Aim:
To describe and characterise fatal adverse reactions associated with ceftriaxone sodium administration in Syrian Arab Republic.
Methods:
We conducted a retrospective analysis of 14 fatal cases of ceftriaxone-associated adverse reactions reported to the national pharmacovigilance system in Syrian Arab Republic from 2018 to 2023.
Results:
Fourteen ceftriaxone sodium-associated fatal ADR cases were identified, including one maternal-foetal case, accounting for 15 deaths. Most fatalities resulted from immediate anaphylactic reactions following intravenous or intramuscular administration. Fatal outcomes included maternal-foetal death, Stevens-Johnson syndrome with multiorgan failure and anaphylaxis occurring during an intradermal allergy test.
Conclusion:
Fatal adverse reactions to ceftriaxone were predominantly rapid and unpredictable, underscoring the need for careful allergy assessment, close patient monitoring and adherence to safe administration practices.
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