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Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture
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Building Up Skin Models for Numerous Applications - from Two-Dimensional (2D) Monoculture to Three-Dimensional (3D) Multiculture

Published on: October 20, 2023

Protocol for reconstructing 3D human skin equivalents on endogenous dermal matrix with optional pigmentation

Khek-Chian Tham1, Zhi Heng Lau1, Joycelyn X Y Lee1

  • 1A∗STAR Skin Research Labs (A∗ SRL), Agency for Science, Technology and Research (A∗STAR), 11 Mandalay Road, #17-01 Clinical Sciences Building, Singapore 308232, Singapore.

STAR Protocols
|July 16, 2026
PubMed

Keywords:
Cell DifferentiationHealth SciencesMolecular BiologyProtein BiochemistryTissue Engineering

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Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...